Medical Biology and Genetics (Master) (with Thesis) Preview
Master	TR-NQF-HE: Level 7	QF-EHEA: Second Cycle	EQF-LLL: Level 7

Course Introduction and Application Information

Course Code:

TGY5106

Course Name:

Epigenetics

Semester:

Fall

Course Credits:

ECTS

Language of instruction:

Turkish

Course Condition:

Does the Course Require Work Experience?:

Type of course:

Departmental Elective

Course Level:

Master

TR-NQF-HE:7. Master`s Degree

QF-EHEA:Second Cycle

EQF-LLL:7. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator:

Dr. Öğr. Üy. MURADİYE ACAR

Course Lecturer(s):

MURADİYE ACAR

Course Assistants:

Course Objective and Content

Course Objectives:	The aim of the course is to know the basic epigenetic mechanisms and to explain how these mechanisms change the chromatin structure. It is aimed to know the methods used in the analysis of gene-specific DNA methylation. To understand the importance of epigenetic changes in cancer.
Course Content:	INTRODUCTION TO EPIGENETICS, DNA METHYLATION, HISTONE MODIFICATIONS, GENE SPECIFIC DNA METHYLATION ANALYSIS, DNA HYPOMETHYLATION IN CANCER, HISTONE MODIFICATIONS IN CANCER, GENE EXPRESSION CHANGES IN TUMOR FORMATION, MIRNA BIOGENESIS, THE ROLE OF MIRNAS IN CANCER, EPIGENETIC REGULATION OF MEZENCHYMAL STEM CELL

Learning Outcomes

The students who have succeeded in this course;
1) Defines Epigenetics
2) DEFINES DNA METHYLATION MECHANISM AND KNOWS HOW IT AFFECTS CHROMATIN STRUCTURE.
3) KNOWS HISTON MODIFICATIONS
4) KNOWS HOW HISTON MODIFICATIONS AFFECT THE CHROMATIN STRUCTURE.
5) UNDERSTAND THE LOGIC OF METHODS USED IN THE ANALYSIS OF GENE SPECIFIC DNA METHYLATION
6) KNOWS THE METHODS USED IN THE ANALYSIS OF GENE SPECIFIC DNA METHYLATION
7) UNDERSTAND HOW DNA HYPERMETHYLATION AFFECTS GENE EXPRESSION IN CANCER
8) UNDERSTAND HOW DNA HYPOMETHYLATION AFFECTS GENE EXPRESSION IN CANCER
9) UNDERSTAND HOW HISTON MODIFICATIONS AFFECT THE CHROMATIN STRUCTURE IN CANCER
10) KNOWS GENE EXPRESSION CHANGES IN TUMOROGENESIS
11) UNDERSTANDS THE IMPORTANCE OF MIRNAS IN CANCER
12) KNOWS THE EPIGENETIC REGULATION OF THE MESENCHYMAL STEM CELL

Course Flow Plan

Week	Subject	Related Preparation
1)	WHAT IS EPIGENETICS?
2)	DNA Methylation
3)	Histone Modiﬁcations-1
4)	Histone Modiﬁcations-2
5)	GENE SPECIFIC DNA METHYLATION ANALYSIS METHODS-1
6)	GENE SPECIFIC DNA METHYLATION ANALYSIS METHODS-2
7)	DNA HYPERMETHYLATION IN CANCER
8)	MİD TERM
9)	DNA Hypomethylation in Cancer
10)	Histone Modifications in Cancer
11)	GENE EXPRESSION CHANGES IN TUMOROGENESIS
12)	THE ROLE OF MIRNAS IN CANCER
13)	EPIGENETIC REGULATION OF MESENCHYMAL STEM CEL
14)	FINAL EXAM

Sources

Course Notes / Textbooks:	"Handbook of Epigenetics Tne New Molecular and Medical Genetics Edited by Trygve Tollefsbol 2011, Elsevier" Epigenetic Alterations in Oncogenesis Edited by Adam R. Karpf Springer 2013
References:	Öğretim üyesi ve öğrenciler tarafından hazırlanan sunumlar, kitaplar

Course - Program Learning Outcome Relationship

Course Learning Outcomes	1	2	3	4	5	6	7	8	9	10	11	12
Program Outcomes
1) Makes necessary assessment, analysis, description and planning using knowledge, skills and attitudes related to the field of Medical Biology and Genetics.
2) Applying the highest level of knowledge and skills in the field of Medical Biology and Genetics to the protection and improvement of the health of society.
3) Applies at the highest level using advanced knowledge and skills required by the field of Medical Biology and Genetics in the case of disease.
4) Healthy and sick individuals who deviate Medical Biology and Genetic requirements in every environment in accordance with contemporary approaches, plan, apply and evaluate genetic program.
5) Implementing the Medical Biology and Genetics program systematically and safely in the framework of ethical principles, using advanced knowledge, skills and professional attainments gained; to terminate or change it where necessary, role models and collections for colleagues.
6) Contributes to the production and implementation of health policies in accordance with the changing and diverse needs of the society in the field of Medical Biology and Genetics.
7) Organizes Medical Biology and Genetics services effectively and adequately and manages the business processes necessary for the continuity and development of the quality and organizational function; it produces solutions to the problems in the direction of information and evidence.
8) Carry out independent vocational and academic work by using the knowledge gained and work as a team member in effective communication and cooperation with other occupational groups working on this field.	1	1	1	1	1	1	1	1	1	1	1	1
9) Records and reports on quality services and research in the field of Medical Biology and Genetics; participates in all phases of research and project implementation.
10) Adopt life-long learning for the continuity of personal development; use information technologies; quality improvement and field related education and promotion programs.

Course - Learning Outcome Relationship

No Effect	1 Lowest	2 Average	3 Highest

	Program Outcomes	Level of Contribution
1)	Makes necessary assessment, analysis, description and planning using knowledge, skills and attitudes related to the field of Medical Biology and Genetics.	1
2)	Applying the highest level of knowledge and skills in the field of Medical Biology and Genetics to the protection and improvement of the health of society.
3)	Applies at the highest level using advanced knowledge and skills required by the field of Medical Biology and Genetics in the case of disease.	2
4)	Healthy and sick individuals who deviate Medical Biology and Genetic requirements in every environment in accordance with contemporary approaches, plan, apply and evaluate genetic program.
5)	Implementing the Medical Biology and Genetics program systematically and safely in the framework of ethical principles, using advanced knowledge, skills and professional attainments gained; to terminate or change it where necessary, role models and collections for colleagues.
6)	Contributes to the production and implementation of health policies in accordance with the changing and diverse needs of the society in the field of Medical Biology and Genetics.
7)	Organizes Medical Biology and Genetics services effectively and adequately and manages the business processes necessary for the continuity and development of the quality and organizational function; it produces solutions to the problems in the direction of information and evidence.
8)	Carry out independent vocational and academic work by using the knowledge gained and work as a team member in effective communication and cooperation with other occupational groups working on this field.
9)	Records and reports on quality services and research in the field of Medical Biology and Genetics; participates in all phases of research and project implementation.
10)	Adopt life-long learning for the continuity of personal development; use information technologies; quality improvement and field related education and promotion programs.

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Presentation	1	% 40
Midterms	1	% 30
Final	1	% 30
total		% 100
PERCENTAGE OF SEMESTER WORK		% 70
PERCENTAGE OF FINAL WORK		% 30
total		% 100

Workload and ECTS Credit Calculation

Activities	Number of Activities	Workload
Course Hours	14	28
Study Hours Out of Class	14	140
Presentations / Seminar	14	28
Homework Assignments	2	6
Midterms	1	3
Final	1	3
Total Workload		208