| Medical Biology and Genetics (DR) | |||||
| PhD | TR-NQF-HE: Level 8 | QF-EHEA: Third Cycle | EQF-LLL: Level 8 | ||
| Course Code: | TGY6004 | ||||
| Course Name: | Microorganism Genetics | ||||
| Semester: | Fall | ||||
| Course Credits: |
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| Language of instruction: | Turkish | ||||
| Course Condition: | |||||
| Does the Course Require Work Experience?: | No | ||||
| Type of course: | Departmental Elective | ||||
| Course Level: |
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| Mode of Delivery: | Face to face | ||||
| Course Coordinator: | Prof. Dr. PINAR YURDAKUL MESUTOĞLU | ||||
| Course Lecturer(s): | Prof Dr Pınar Yurdakul-Mesutoğlu | ||||
| Course Assistants: |
| Course Objectives: | Microorganism genetics is the study of the mechanisms of heritable information in microorganisms, including bacteria, archaea, viruses, some protozoa and fungi. Microbial Genetics deals with the transmission of heritable traits by microbes and the methods and principles used to study inheritance. The role of genetic variation in driving microbial evolution will be an underlying theme. We will also explore how knowledge of natural genetic processes in bacteria such as conjugation, transformation and transduction has been utilized under controlled conditions to produce desirable/valuable traits. We will learn about state-of-the-art concepts and approaches developed in the last three decades that are revolutionizing our ability to understand core genomes, comparative genomics, metagenomics and various drivers of genetic and physiological biodiversity. In addition, microorganism omics, biotechnological approraches as well antibiotic resistance mechanisms will be discussed. |
| Course Content: | The nature of microbial nucleic acids and their amplification; molecular hybridization for microbial identification; molecular typing; new technologies; omics in microorganisms; molecular detection of microorganisms; systems microbiology; the pathogen/host interface; antibiotic resistance mechanisms; clinical application of microbial genetics; biotechnological application of microbial genetics |
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The students who have succeeded in this course;
1) Sound understanding of the core principles, paradigms and unique aspects of microbial genetics. 2) Familiarity with historically important, contemporary, and state-of-the-art research techniques used in microbial genetics. 3) Development of skills in critical thinking, integration/synthesis of concepts and ideas and scientific problem-solving. 4) Describe the relationship between genotype and phenotype 5) Describe the difference between genetic selections, screens, and enrichments and how each can be used to isolate particular types of mutants 6) Describe the mechanisms of gene exchange by transformation, conjugation, and transduction 7) Describe how Hfr’s are formed and how they can be used to map genes 8) Describe the major classes of transposons, the mechanism of transposition, and the utility of transposons for genetic analysis 9) Describe the mechanism of common regulatory systems including the lac operon, the ara operon, and two component regulatory systems 10) Describe the developmental cycles of phage, and how genetic and molecular approaches can be used to identify these processes 11) Explain the clinical uses of microbial genetics-based methods 12) Explain the use of microbial genetics-based methods in biotechnology 13) Explain microbial omics and their application areas |
| Week | Subject | Related Preparation |
| 1) | Core principles, paradigms and unique aspects of microbial genetics. | |
| 2) | Historically important, contemporary, and state-of-the-art research techniques used in microbial genetics | |
| 3) | The relationship between genotype and phenotype | |
| 4) | Gene exchange by transformation, conjugation, and transduction | |
| 5) | Hfr mechanism | |
| 6) | Major classes of transposons, the mechanism of transposition, and the utility of transposons for genetic analysis | |
| 7) | The mechanism of common regulatory systems including the lac operon, the ara operon, and two component regulatory systems | |
| 8) | Phages | |
| 9) | The clinical uses of microbial genetics-based methods | |
| 10) | To explain the use of microbial genetics-based methods in biotechnology | |
| 11) | Microbial omics |
| Course Notes / Textbooks: | Thompson & Thompson Genetics and Genomics in Medicine, 9th Edition Klug and Cummings, Concepts of Genetics, 12th Edition |
| References: | Thompson & Thompson Genetics and Genomics in Medicine, 9th Edition Klug and Cummings, Concepts of Genetics, 12th Edition |
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| Program Outcomes | |||||||||||||
| 1) Follows the current literature in the field of Medical Biology and Genetics, collects information, analyzes and synthesizes it with appropriate evaluation methods and guides clinical practices. | |||||||||||||
| 2) Uses appropriate methods and technological structures for scientific research, establishes the appropriate hypothesis, and determines research methods. | |||||||||||||
| 3) Interprets the results obtained as a result of scientific research, transfers and develops the evidence-based knowledge obtained into applications, presents its results at national and international scientific meetings and publishes them in peer-reviewed journals. | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 4) Realizes the principles of lifelong learning by observing professional autonomy within the ethical, deontological and legal framework in Medical Biology and Genetics applications and scientific studies. | |||||||||||||
| 5) Provides interdisciplinary collaboration in academic and clinical environments and has knowledge and skills in problem solving and management. | |||||||||||||
| 6) Uses the information obtained from scientific research and literature for the benefit of society and ensures the shaping of health policies necessary to improve public health and takes part in these policies. | |||||||||||||
| 7) Trains biologists who combine clinical experience and academic knowledge, produce, plan and implement creative solutions in the field of medical biology and have qualified knowledge and skills. | |||||||||||||
| No Effect | 1 Lowest | 2 Average | 3 Highest |
| Program Outcomes | Level of Contribution | |
| 1) | Follows the current literature in the field of Medical Biology and Genetics, collects information, analyzes and synthesizes it with appropriate evaluation methods and guides clinical practices. | 2 |
| 2) | Uses appropriate methods and technological structures for scientific research, establishes the appropriate hypothesis, and determines research methods. | |
| 3) | Interprets the results obtained as a result of scientific research, transfers and develops the evidence-based knowledge obtained into applications, presents its results at national and international scientific meetings and publishes them in peer-reviewed journals. | |
| 4) | Realizes the principles of lifelong learning by observing professional autonomy within the ethical, deontological and legal framework in Medical Biology and Genetics applications and scientific studies. | |
| 5) | Provides interdisciplinary collaboration in academic and clinical environments and has knowledge and skills in problem solving and management. | |
| 6) | Uses the information obtained from scientific research and literature for the benefit of society and ensures the shaping of health policies necessary to improve public health and takes part in these policies. | |
| 7) | Trains biologists who combine clinical experience and academic knowledge, produce, plan and implement creative solutions in the field of medical biology and have qualified knowledge and skills. | 1 |
| Semester Requirements | Number of Activities | Level of Contribution |
| Midterms | 1 | % 40 |
| Final | 1 | % 60 |
| total | % 100 | |
| PERCENTAGE OF SEMESTER WORK | % 40 | |
| PERCENTAGE OF FINAL WORK | % 60 | |
| total | % 100 | |
| Activities | Number of Activities | Preparation for the Activity | Spent for the Activity Itself | Completing the Activity Requirements | Workload | ||
| Course Hours | 13 | 4 | 2 | 78 | |||
| Study Hours Out of Class | 13 | 0 | 10 | 130 | |||
| Midterms | 2 | 0 | 0 | ||||
| Final | 2 | 0 | 0 | ||||
| Total Workload | 208 | ||||||