| Medical Biology and Genetics (DR) | |||||
| PhD | TR-NQF-HE: Level 8 | QF-EHEA: Third Cycle | EQF-LLL: Level 8 | ||
| Course Code: | TGY6013 | ||||
| Course Name: | Epigenetics | ||||
| Semester: | Spring | ||||
| Course Credits: |
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| Language of instruction: | Turkish | ||||
| Course Condition: | |||||
| Does the Course Require Work Experience?: | No | ||||
| Type of course: | Departmental Elective | ||||
| Course Level: |
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| Mode of Delivery: | Face to face | ||||
| Course Coordinator: | Dr. Öğr. Üy. MURADİYE ACAR | ||||
| Course Lecturer(s): | MURADİYE ACAR | ||||
| Course Assistants: |
| Course Objectives: | The aim of the course is to explain epigenetic mechanisms and their roles in regulating gene expression. It aims to provide information about the techniques used in epigenetic research. The impact of epigenetic disorders on cancer and human diseases will be examined. |
| Course Content: | Epigenetics: The New Science of Genetics, Mechanisms of DNA Methylation, Mechanisms of Histone Modifications, The Epigenetics of Non-coding RNA, Analysis of Gene-specific DNA Methylation/ Methods for Assessing Genome-wide DNA Methylation, DNA Hypomethylation in Cancer, Altered Histone Modifications in Cancer, Gene Regulation During Tumorigenesis, Epigenetic Regulation of miRNAs in Cancer, Epigenetic Regulation of miRNAs in Cancer, Epigenetic Changes During Cell Transformation, Epigenetic Reprogramming of Mesenchymal Stem Cells, Epigenetic Targeting Therapies to Overcome |
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The students who have succeeded in this course;
1) Defines epigenetic and epigenetic mechanisms 2) Knows the DNA methylation mechanism and defines its relationship with gene expression. 3) Understands the Histone modification mechanism and defines its relationship with gene expression 4) Defines non -coding RNAs and explains their importance in epigenetic regulation. 5) Knows the methods used in the analysis of gene specific DNA methylation and Genome Wide DNA methylation. 6) Knows the importance of DNA hypometlation changes in cancer. 7) Comprehends how histone modification changes affect cancer. 8) Knows the importance of gene regulation in tumorogenesis and how it changes. 9) Knows the biogenesis of MiRNA and its regulation in cancer 10) Defines epigenetic changes in transformation 11) Understands the Mesenchymal stem cell epigenetic re -programming mechanism of the cell. 12) Describes chemotherapy resistance and epigenetic treatments |
| Week | Subject | Related Preparation |
| 1) | Epigenetics: The New Science of Genetics | |
| 2) | Mechanisms of DNA Methylation | |
| 3) | Mechanisms of Histone Modifications | |
| 4) | The Epigenetics of Non-coding RNA | |
| 5) | Analysis of Gene-specific DNA Methylation/ Methods for Assessing Genome-wide DNA Methylation | |
| 6) | DNA Hypomethylation in Cancer | |
| 7) | Altered Histone Modifications in Cancer | |
| 8) | MID TERM | |
| 9) | Gene Regulation During Tumorigenesis | |
| 10) | Epigenetic Regulation of miRNAs in Cancer | |
| 11) | Epigenetic Changes During Cell Transformation | |
| 12) | Epigenetic Reprogramming of Mesenchymal Stem Cells | |
| 13) | Epigenetic Therapies and Chemotherapy Resistance | |
| 14) | FINAL EXAM |
| Course Notes / Textbooks: | "Handbook of Epigenetics Tne New Molecular and Medical Genetics Edited by Trygve Tollefsbol 2011, Elsevier" Epigenetic Alterations in Oncogenesis Edited by Adam R. Karpf Springer 2013 |
| References: | Öğretim üyesi ve öğrenciler tarafından hazırlanan sunumlar, ders kitapları |
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| Program Outcomes | ||||||||||||
| 1) Follows the current literature in the field of Medical Biology and Genetics, collects information, analyzes and synthesizes it with appropriate evaluation methods and guides clinical practices. | ||||||||||||
| 2) Uses appropriate methods and technological structures for scientific research, establishes the appropriate hypothesis, and determines research methods. | ||||||||||||
| 3) Interprets the results obtained as a result of scientific research, transfers and develops the evidence-based knowledge obtained into applications, presents its results at national and international scientific meetings and publishes them in peer-reviewed journals. | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| 4) Realizes the principles of lifelong learning by observing professional autonomy within the ethical, deontological and legal framework in Medical Biology and Genetics applications and scientific studies. | ||||||||||||
| 5) Provides interdisciplinary collaboration in academic and clinical environments and has knowledge and skills in problem solving and management. | ||||||||||||
| 6) Uses the information obtained from scientific research and literature for the benefit of society and ensures the shaping of health policies necessary to improve public health and takes part in these policies. | ||||||||||||
| 7) Trains biologists who combine clinical experience and academic knowledge, produce, plan and implement creative solutions in the field of medical biology and have qualified knowledge and skills. | ||||||||||||
| No Effect | 1 Lowest | 2 Average | 3 Highest |
| Program Outcomes | Level of Contribution | |
| 1) | Follows the current literature in the field of Medical Biology and Genetics, collects information, analyzes and synthesizes it with appropriate evaluation methods and guides clinical practices. | 2 |
| 2) | Uses appropriate methods and technological structures for scientific research, establishes the appropriate hypothesis, and determines research methods. | |
| 3) | Interprets the results obtained as a result of scientific research, transfers and develops the evidence-based knowledge obtained into applications, presents its results at national and international scientific meetings and publishes them in peer-reviewed journals. | |
| 4) | Realizes the principles of lifelong learning by observing professional autonomy within the ethical, deontological and legal framework in Medical Biology and Genetics applications and scientific studies. | |
| 5) | Provides interdisciplinary collaboration in academic and clinical environments and has knowledge and skills in problem solving and management. | |
| 6) | Uses the information obtained from scientific research and literature for the benefit of society and ensures the shaping of health policies necessary to improve public health and takes part in these policies. | |
| 7) | Trains biologists who combine clinical experience and academic knowledge, produce, plan and implement creative solutions in the field of medical biology and have qualified knowledge and skills. | 1 |
| Semester Requirements | Number of Activities | Level of Contribution |
| Presentation | 1 | % 40 |
| Midterms | 1 | % 30 |
| Final | 1 | % 30 |
| total | % 100 | |
| PERCENTAGE OF SEMESTER WORK | % 70 | |
| PERCENTAGE OF FINAL WORK | % 30 | |
| total | % 100 | |
| Activities | Number of Activities | Workload |
| Course Hours | 14 | 42 |
| Study Hours Out of Class | 14 | 56 |
| Presentations / Seminar | 12 | 48 |
| Homework Assignments | 12 | 36 |
| Midterms | 1 | 3 |
| Final | 1 | 3 |
| Total Workload | 188 | |