Molecular Oncology (DR) Preview
PhD	TR-NQF-HE: Level 8	QF-EHEA: Third Cycle	EQF-LLL: Level 8

Course Introduction and Application Information

Course Code:

MONK6004

Course Name:

Cancer Biochemistry

Semester:

Fall

Course Credits:

ECTS

Language of instruction:

Turkish

Course Condition:

Does the Course Require Work Experience?:

Yes

Type of course:

Departmental Elective

Course Level:

PhD

TR-NQF-HE:8. Master`s Degree

QF-EHEA:Third Cycle

EQF-LLL:8. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator:

Dr. Öğr. Üy. MURAT EKREMOĞLU

Course Lecturer(s):

Asst. Prof. Murat Ekremoğlu, Asst. Prof. Yelda Birinci Kudu, Asst Prof. Caner Geyik, Asst. Prof. Huri Bulut

Course Assistants:

Course Objective and Content

Course Objectives:	To learn the molecular and biochemical mechanisms involved in cancer formation and progression, the principles of using these mechanisms in the diagnosis and treatment of cancer, and the evaluation of current research articles on related subjects.
Course Content:	Biochemical markers of cancer, biochemical changes occurring in the process of cancerization, the relationship of metabolic processes with cancer.

Learning Outcomes

The students who have succeeded in this course;
1) To analyze biochemical differences between normal and cancerous cells
2) To be able to define cancer-forming agents, to associate them with cancer mechanisms
3) To be able to interpret the mechanisms and innovations related to the growth control of cancer cells
4) To be able to evaluate the biochemistry of cancer genes, growth factors, cell proliferation and differentiation
5) To be able to combine, interpret and present knowledge about biochemistry, cancer genetics and biology

Course Flow Plan

Week	Subject	Related Preparation
1)	Introduction to cancer biochemistry
2)	Cell Cycle
3)	Programmed Cell Death (Apoptosis)
4)	Unprogrammed Cell Death (Autophagy/Necrosis)
5)	Physiological and Chemical Factors in Cancer
6)	Cancer-Carbohydrate Metabolism-I
7)	Cancer-Carbohydrate Metabolism-II
8)	Hypoxia-cancer
9)	Oxidative stress-Cancer
10)	Biochemical Routine and Research Methods Used in Cancer Diagnosis and Treatment
11)	Biomarkers in the Diagnosis of Cancer
12)	New approaches in cancer treatment and drug development
13)	Drug resistance in cancer
14)	Final homework submission

Sources

Course Notes / Textbooks:	- The biology of cancer (ISNB 978-0815342205)
References:	- Lehninger principle of biochemistry. (ISNB 978-1429234146) - Lippincott: biochemistry 7th edition (ISBN 978-1496344496) - Harper’s biochemistry (ISBN 978-1260288421)

Course - Program Learning Outcome Relationship

Course Learning Outcomes	1	2	3	4	5
Program Outcomes
1) To be able to define, evaluate and use current and advanced knowledge of cancer and molecular cancer
2) To be able to research, comprehend and analyze a scientific and technological issue in the field of molecular cancer with a systematic approach.
3) Ability to develop, design, adapt and implement new and complex ideas about the molecular mechanisms of cancer at an expert level with original thinking and/or research
4) To be able to comprehend the interdisciplinary interaction with which the molecular cancer field is related, to develop a new method, design and/or application with a new idea or a known idea.
5) To gain the ability to synthesize, analyze, interpret, question and criticize information about treatment approaches developed against cancer
6) Tp develop new ideas and methods in the field by using high-level skills such as problem solving and decision making in their studies.
7) To have good communication skills in their work and being able to critically examine and develop the norms that guide these relationships, and to manage actions to change them when necessary
8) To have an awareness of ethical responsibility in their research and to be able to defend their findings by using advanced written, verbal and visual communication.
9) To contribute to the solution of social, scientific, computational and ethical problems encountered in the field of molecular cancer and to support the development of these values.
10) To be able to interpret research and study results and expand the limits of knowledge in the field by producing an original work.

Course - Learning Outcome Relationship

No Effect	1 Lowest	2 Average	3 Highest

	Program Outcomes	Level of Contribution
1)	To be able to define, evaluate and use current and advanced knowledge of cancer and molecular cancer
2)	To be able to research, comprehend and analyze a scientific and technological issue in the field of molecular cancer with a systematic approach.
3)	Ability to develop, design, adapt and implement new and complex ideas about the molecular mechanisms of cancer at an expert level with original thinking and/or research
4)	To be able to comprehend the interdisciplinary interaction with which the molecular cancer field is related, to develop a new method, design and/or application with a new idea or a known idea.
5)	To gain the ability to synthesize, analyze, interpret, question and criticize information about treatment approaches developed against cancer
6)	Tp develop new ideas and methods in the field by using high-level skills such as problem solving and decision making in their studies.
7)	To have good communication skills in their work and being able to critically examine and develop the norms that guide these relationships, and to manage actions to change them when necessary
8)	To have an awareness of ethical responsibility in their research and to be able to defend their findings by using advanced written, verbal and visual communication.
9)	To contribute to the solution of social, scientific, computational and ethical problems encountered in the field of molecular cancer and to support the development of these values.
10)	To be able to interpret research and study results and expand the limits of knowledge in the field by producing an original work.

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Homework Assignments	1	% 10
Presentation	1	% 10
Midterms	1	% 30
Final	1	% 50
total		% 100
PERCENTAGE OF SEMESTER WORK		% 50
PERCENTAGE OF FINAL WORK		% 50
total		% 100

Workload and ECTS Credit Calculation

Activities	Number of Activities	Preparation for the Activity	Spent for the Activity Itself	Completing the Activity Requirements	Workload
Course Hours	14	2	1		42
Study Hours Out of Class	35	0	2		70
Presentations / Seminar	1	25			25
Homework Assignments	1	10	5		15
Midterms	1	20	1		21
Final	1	20			20
Total Workload					193