Molecular Oncology (DR) Preview
PhD	TR-NQF-HE: Level 8	QF-EHEA: Third Cycle	EQF-LLL: Level 8

Course Introduction and Application Information

Course Code:

MONK6206

Course Name:

Experimental Animal Models in Cancer Research

Semester:

Spring

Course Credits:

ECTS

Language of instruction:

Turkish

Course Condition:

Does the Course Require Work Experience?:

Yes

Type of course:

Departmental Elective

Course Level:

PhD

TR-NQF-HE:8. Master`s Degree

QF-EHEA:Third Cycle

EQF-LLL:8. Master`s Degree

Mode of Delivery:

E-Learning

Course Coordinator:

Doç. Dr. HURİ DEDEAKAYOĞULLARI

Course Lecturer(s):

Huri Bulut

Course Assistants:

Course Objective and Content

Course Objectives:	The aim of this course is to make students comprehend the content, importance, methods and fields of studies with experimental animals, which have a very important place in the field of experimental oncology and in planning oncology research.
Course Content:	Selection of experimental animals in oncological studies, ethics of experimental animals, tumor models, metastasis models and drug applications in experimental animals.

Learning Outcomes

The students who have succeeded in this course;
1) To understand the importance and place of the use of experimental animals in oncology research.
2) To know which experimental animal is used for what purpose in oncology research,
3) To learn the methods of creating a tumor model in experimental animals.
4) To comprehend the ethical aspects to be considered in studies using experimental animals.
5) To be able to plan an oncology-related experimental animal study

Course Flow Plan

Week	Subject	Related Preparation
1)	The place of experimental animals in oncological studies	1.Biyomedikal Araştırmalarda Deney Hayvanı "Temel Bilgiler ve Etik İlkeler Yeğen B, Gören Z eds. Yüce yayınevi, 2005 2 Deney hayvanları, Laboratuar teknikleri, Başaran A. Nisan kitabevi, 3 The Laboratory Mouse, Hans Hedrich, Academic Press, 2004, ISBN 978-0123364258 4 The Laboratory Rat, George J. Krinke, Academic Press, 2000, ISBN 978-0124264007
2)	Ethics in oncology experimental animal studies	1.Biyomedikal Araştırmalarda Deney Hayvanı "Temel Bilgiler ve Etik İlkeler Yeğen B, Gören Z eds. Yüce yayınevi, 2005 2 Deney hayvanları, Laboratuar teknikleri, Başaran A. Nisan kitabevi, 3 The Laboratory Mouse, Hans Hedrich, Academic Press, 2004, ISBN 978-0123364258 4 The Laboratory Rat, George J. Krinke, Academic Press, 2000, ISBN 978-0124264007
3)	Principles of use of immunosuppressed experimental animals	1.Biyomedikal Araştırmalarda Deney Hayvanı "Temel Bilgiler ve Etik İlkeler Yeğen B, Gören Z eds. Yüce yayınevi, 2005 2 Deney hayvanları, Laboratuar teknikleri, Başaran A. Nisan kitabevi, 3 The Laboratory Mouse, Hans Hedrich, Academic Press, 2004, ISBN 978-0123364258 4 The Laboratory Rat, George J. Krinke, Academic Press, 2000, ISBN 978-0124264007
4)	Spontaneous tumor models	1.Biyomedikal Araştırmalarda Deney Hayvanı "Temel Bilgiler ve Etik İlkeler Yeğen B, Gören Z eds. Yüce yayınevi, 2005 2 Deney hayvanları, Laboratuar teknikleri, Başaran A. Nisan kitabevi, 3 The Laboratory Mouse, Hans Hedrich, Academic Press, 2004, ISBN 978-0123364258 4 The Laboratory Rat, George J. Krinke, Academic Press, 2000, ISBN 978-0124264007
5)	Induced tumor models	1.Biyomedikal Araştırmalarda Deney Hayvanı "Temel Bilgiler ve Etik İlkeler Yeğen B, Gören Z eds. Yüce yayınevi, 2005 2 Deney hayvanları, Laboratuar teknikleri, Başaran A. Nisan kitabevi, 3 The Laboratory Mouse, Hans Hedrich, Academic Press, 2004, ISBN 978-0123364258 4 The Laboratory Rat, George J. Krinke, Academic Press, 2000, ISBN 978-0124264007
6)	Use of transgenic technology in oncological studies	1.Biyomedikal Araştırmalarda Deney Hayvanı "Temel Bilgiler ve Etik İlkeler Yeğen B, Gören Z eds. Yüce yayınevi, 2005 2 Deney hayvanları, Laboratuar teknikleri, Başaran A. Nisan kitabevi, 3 The Laboratory Mouse, Hans Hedrich, Academic Press, 2004, ISBN 978-0123364258 4 The Laboratory Rat, George J. Krinke, Academic Press, 2000, ISBN 978-0124264007
7)	EXAM
8)	Creating a metastasis model in experimental animals	1.Biyomedikal Araştırmalarda Deney Hayvanı "Temel Bilgiler ve Etik İlkeler Yeğen B, Gören Z eds. Yüce yayınevi, 2005 2 Deney hayvanları, Laboratuar teknikleri, Başaran A. Nisan kitabevi, 3 The Laboratory Mouse, Hans Hedrich, Academic Press, 2004, ISBN 978-0123364258 4 The Laboratory Rat, George J. Krinke, Academic Press, 2000, ISBN 978-0124264007
9)	Follow-up and imaging of tumor and related factors in experimental animals	1.Biyomedikal Araştırmalarda Deney Hayvanı "Temel Bilgiler ve Etik İlkeler Yeğen B, Gören Z eds. Yüce yayınevi, 2005 2 Deney hayvanları, Laboratuar teknikleri, Başaran A. Nisan kitabevi, 3 The Laboratory Mouse, Hans Hedrich, Academic Press, 2004, ISBN 978-0123364258 4 The Laboratory Rat, George J. Krinke, Academic Press, 2000, ISBN 978-0124264007
10)	Oncology-related drug applications in experimental animals	1.Biyomedikal Araştırmalarda Deney Hayvanı "Temel Bilgiler ve Etik İlkeler Yeğen B, Gören Z eds. Yüce yayınevi, 2005 2 Deney hayvanları, Laboratuar teknikleri, Başaran A. Nisan kitabevi, 3 The Laboratory Mouse, Hans Hedrich, Academic Press, 2004, ISBN 978-0123364258 4 The Laboratory Rat, George J. Krinke, Academic Press, 2000, ISBN 978-0124264007
11)	Carcinogen studies in experimental animals	1.Biyomedikal Araştırmalarda Deney Hayvanı "Temel Bilgiler ve Etik İlkeler Yeğen B, Gören Z eds. Yüce yayınevi, 2005 2 Deney hayvanları, Laboratuar teknikleri, Başaran A. Nisan kitabevi, 3 The Laboratory Mouse, Hans Hedrich, Academic Press, 2004, ISBN 978-0123364258 4 The Laboratory Rat, George J. Krinke, Academic Press, 2000, ISBN 978-0124264007
12)	Article Evaluation
13)	Article Evaluation
14)	Final exam

Sources

Course Notes / Textbooks:	1. Biyomedikal Araştırmalarda Deney Hayvanı "Temel Bilgiler ve Etik İlkeler Yeğen B, Gören Z eds. Yüce yayınevi, 2005 2. Deney hayvanları, Laboratuar teknikleri, Başaran A. Nisan kitabevi, 3. The Laboratory Mouse, Hans Hedrich, Academic Press, 2004, ISBN 978-0123364258 4. The Laboratory Rat, George J. Krinke, Academic Press, 2000, ISBN 978-0124264007
References:	1. Biyomedikal Araştırmalarda Deney Hayvanı "Temel Bilgiler ve Etik İlkeler Yeğen B, Gören Z eds. Yüce yayınevi, 2005 2. Deney hayvanları, Laboratuar teknikleri, Başaran A. Nisan kitabevi, 3. The Laboratory Mouse, Hans Hedrich, Academic Press, 2004, ISBN 978-0123364258 4. The Laboratory Rat, George J. Krinke, Academic Press, 2000, ISBN 978-0124264007

Course - Program Learning Outcome Relationship

Course Learning Outcomes	1	2	3	4	5
Program Outcomes
1) To be able to define, evaluate and use current and advanced knowledge of cancer and molecular cancer
2) To be able to research, comprehend and analyze a scientific and technological issue in the field of molecular cancer with a systematic approach.
3) Ability to develop, design, adapt and implement new and complex ideas about the molecular mechanisms of cancer at an expert level with original thinking and/or research
4) To be able to comprehend the interdisciplinary interaction with which the molecular cancer field is related, to develop a new method, design and/or application with a new idea or a known idea.
5) To gain the ability to synthesize, analyze, interpret, question and criticize information about treatment approaches developed against cancer
6) Tp develop new ideas and methods in the field by using high-level skills such as problem solving and decision making in their studies.
7) To have good communication skills in their work and being able to critically examine and develop the norms that guide these relationships, and to manage actions to change them when necessary
8) To have an awareness of ethical responsibility in their research and to be able to defend their findings by using advanced written, verbal and visual communication.
9) To contribute to the solution of social, scientific, computational and ethical problems encountered in the field of molecular cancer and to support the development of these values.
10) To be able to interpret research and study results and expand the limits of knowledge in the field by producing an original work.

Course - Learning Outcome Relationship

No Effect	1 Lowest	2 Average	3 Highest

	Program Outcomes	Level of Contribution
1)	To be able to define, evaluate and use current and advanced knowledge of cancer and molecular cancer	2
2)	To be able to research, comprehend and analyze a scientific and technological issue in the field of molecular cancer with a systematic approach.	3
3)	Ability to develop, design, adapt and implement new and complex ideas about the molecular mechanisms of cancer at an expert level with original thinking and/or research	3
4)	To be able to comprehend the interdisciplinary interaction with which the molecular cancer field is related, to develop a new method, design and/or application with a new idea or a known idea.	2
5)	To gain the ability to synthesize, analyze, interpret, question and criticize information about treatment approaches developed against cancer	2
6)	Tp develop new ideas and methods in the field by using high-level skills such as problem solving and decision making in their studies.	2
7)	To have good communication skills in their work and being able to critically examine and develop the norms that guide these relationships, and to manage actions to change them when necessary	2
8)	To have an awareness of ethical responsibility in their research and to be able to defend their findings by using advanced written, verbal and visual communication.	3
9)	To contribute to the solution of social, scientific, computational and ethical problems encountered in the field of molecular cancer and to support the development of these values.	3
10)	To be able to interpret research and study results and expand the limits of knowledge in the field by producing an original work.	2

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Homework Assignments	1	% 40
Presentation	1	% 60
total		% 100
PERCENTAGE OF SEMESTER WORK		% 100
PERCENTAGE OF FINAL WORK		%
total		% 100

Workload and ECTS Credit Calculation

Activities	Number of Activities	Preparation for the Activity	Spent for the Activity Itself	Completing the Activity Requirements	Workload
Course Hours	2	2	2	28	64
Midterms	1	5	5	15	25
Final	2	10	10	10	60
Total Workload					149