ISTINYE UNIVERSITY BİLGİ PAKETİ / DERS KATALOĞU
| Pharmacy | |||||
| Bachelor | TR-NQF-HE: Level 6 | QF-EHEA: First Cycle | EQF-LLL: Level 6 | ||
Course Introduction and Application Information
| Course Code: | ECZ419 | ||||
| Course Name: | Pharmaceutical Chemistry 4 | ||||
| Semester: | Spring | ||||
| Course Credits: |
|
||||
| Language of instruction: | Turkish | ||||
| Course Condition: | |||||
| Does the Course Require Work Experience?: | No | ||||
| Type of course: | Compulsory Courses | ||||
| Course Level: |
|
||||
| Mode of Delivery: | E-Learning | ||||
| Course Coordinator: | Dr. Öğr. Üy. ONUR ŞAHİN | ||||
| Course Lecturer(s): | Bedia Kaymakçıoğlu, Onur ŞAHİN | ||||
| Course Assistants: |
Course Objective and Content
| Course Objectives: | Aim of this course is to develop knowledge and skills on the synthesis and mechanisms of action of drugs used in gastrointestinal tract, respiratory system and endocrine system diseases drugs. Besides examining the diseases about subject, the purpose and content of this education will allow students as persons who can inform and guide patients about drugs in the treatment with medicines. Aim of this course is to give information about functional group analysis, titrimetric analysis methods based on structure properties (notralization, oxido-reduction reactions, nitritometri, permanganimetri, …) quantitative determination of the amount, purity controls for organic compounds and drug active compounds. This course also gives theoretical and practical knowledge about pharmacopea, practice of pharmacopeia, qualitative and quantitative analysis |
| Course Content: | In this course formula, nomenclature, general physicochemical properties, general synthetic pathways, metabolism, stability, general chemical analysis, structure-activity relationships and therapeutic uses of drugs acting on the digestive system, medications used in ulcer treatment, laxatives, purgatives, antidiarrheal compounds, emetics, anti-emetics, radiodiagnostic drugs, mucolytics, expectorants, antitussives, oral antidiabetics, antihypoglycemics, hormones, steroid hormones, thyroid hormones, thyroid active compounds and antithyroid compounds are taught. In this course pharmacopeia analysis and quantitative determination of pharmaceutically active ingredients by titrimetric methods is taught. Within this subject general information about titrimetric analysis, titrimetric methods (oxido-reduction reactions such as iodometry, nitritometry, permanganometry, titrations in anhydrous conditions and acide-base titration is given. General information about pharmacopeia and practice of pharmaceutically active ingredients in terms of pharmacopeia compliance is also taught in this course. |
Learning Outcomes
|
The students who have succeeded in this course;
1) Primary requirement of Pharmaceutical Chemistry in pharmaceutical industry 2) Design, synthesis, analysis and metabolism of pharmaceutical products 3) Project development and presentation on pharmaceutical teamwork, research and development |
Course Flow Plan
| Week | Subject | Related Preparation |
| 1) | Teo: General Introduction - Lab: Analysis Methods | |
| 2) | Teo: Steroid hormones and their chemical structures Lab: General Information, Acid-Base titrations | |
| 3) | Teo: Gestagenic hormones Lab: General Information, Oxido-Reduction Reactions, Nitritometry, Permanganimetry | |
| 4) | Teo: Anabolics and doping, androstane group anabolics, testosterone anabolics, Thyroid Lab: Quantification of Acetyl salicylic acid | |
| 5) | Teo: Pancreatic hormones-insulin, general information about glucagon, oral antidiabetics Lab: Quantitation of antipyrine | |
| 6) | Teo: Oral antidiabetics, enzyme inhibitors, antihypoglycemics Lab: Quantitation of sulfoguanidine | |
| 7) | Teo: Midterm Exam Lab: Midterm Exam | |
| 8) | Teo: General information about the respiratory system, mucolytics Lab: Quantitation of calcium lactate | |
| 9) | Teo: Expectorants, antitussives Lab: General Information, Pharmacopoeia analysis | |
| 10) | Teo: Drugs acting on the digestive system, digestive system enzymes Lab: Acetyl salicylic acid tablet | |
| 11) | Teo: Medications used in ulcer treatment - Antacids - Drugs that reduce acid secretion - Histamine H2-receptor blockers Lab: Ascorbic acid | |
| 12) | Teo: Antimuskarinik İlaçlar; Proton Pompası İnhibitörleri,Mide Koruyucuları Uyg: Uygulama, Sülfadimidin tablet | |
| 13) | Teo: Emetic and antiemetics -Laxatives and purgatives Lab: Citric acid | |
| 14) | Teo: Prokinetic compounds -Antidiarrheal compounds Lab: Practice, Homework |
Sources
| Course Notes / Textbooks: | 1) Foye Medisinal Kimya Temel İlkeleri, T.L.emke, S.W.Zito, V.F.Roche, D.A.Williams, Çev.Edit.Öztekin Algül, Kayhan Bolelli |
| References: | 1- Farmasötik Kimya Hacettepe Üniversitesi Yayınları ISBN: 978-975-491-171-8 3. Baskı, Aralık 2013 2- Foye's Principles of Medicinal Chemistry Publication Date: March 8, 2012 ISBN-10: 1609133455 ISBN-13: 978-1609133450 Edition: Seventh, North American Edition 3- Burger's Medicinal Chemistry, Drug Discovery and Development 7th Edition, 8 Volume Set ISBN: 978-0-470-27815-4 September 2010 4- Pharmaceutical Chemistry, David G. Watson (Author) Publication Date: February 18, 2011 ISBN-10: 0443072329 ISBN-13: 978-0443072321 Edition: 1 5- Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry Publication Date: March 2, 2010 ISBN-10: 0781779294 ISBN-13: 978-0781779296 Edition: Twelfth, North American Edition |
Course - Program Learning Outcome Relationship
| Course Learning Outcomes | 1 |
2 |
3 |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Program Outcomes | |||||||||||
| 1) Applies and develops the universal and social dimensional effects of basic, professional and technological knowledge in the field of pharmacy as well as pharmacy practice interdisciplinary by following legal, deontological and ethical rules. | 3 | 3 | 3 | ||||||||
| 2) Defines the terminology related to the pharmacy profession; solves problems , accesses scientific information in the field of pharmacy, after monitoring and evaluating the current literature, applies , communicates, shares by using information technologies effectively and efficiently. | 2 | 2 | 2 | ||||||||
| 3) Uses theoretical and practical knowledge about the anatomical structure of the human body, the physiological working principles of systems, biochemical, immunological events in the organism and microorganisms. | |||||||||||
| 4) Uses basic and advanced analytical techniques and methods by running qualitative/quantitative analyzes and interprets the findings by using appropriate statistical methods. | 3 | 3 | 3 | ||||||||
| 5) Defines medicinal plants, herbal drugs and active substances; gains the skills for the development of natural products used for medical purposes. | 1 | 1 | 1 | ||||||||
| 6) Applies patient-centered and individualized pharmaceutical care service together with other healthcare personnel within the framework of rational drug use by using the principles of clinical pharmacy, pharmacoeconomics, pharmacotherapy and phytotherapy. | 1 | 1 | 1 | ||||||||
| 7) Knows the biological properties, structure-activity relationships, and metabolisms of drugs and gains the skill for the synthesize and development of new drug candidates. | 3 | 3 | 3 | ||||||||
| 8) He/She is competent at formulations, production, stability, quality assurance, licensing, patent studies, legal regulations of products containing natural origin and / or synthetic active substances, advanced therapy medicinal products, radiopharmaceuticals and cosmetic products. | |||||||||||
| 9) Interprets the pharmacokinetic and pharmacodynamic properties of drugs, the factors that change their effect, their toxic effects, pharmacolygical activities and their risk assessment method. Reports the drug interactions and adverse drug reactions, monitors and applies the theoretical/practical knowledge for preventing them. | |||||||||||
| 10) As a health professional in his/her profession he/she acts as a caregiver, decision maker, communicator, manager, lifelong learner, instructor, leader and researcher, he/she complies with the principles of evidence-based pharmacy by making teamwork for the benefit of society, national and universal values. | 2 | 2 | 2 | ||||||||
| 11) He/She works in various fields such as community pharmacy, hospitals, pharmaceutical medical devices, herbal products and cosmetics sectors, health institutions and agencies, clinical research organizations , universities and R&D centers. | 2 | 2 | 2 | ||||||||
Course - Learning Outcome Relationship
| No Effect | 1 Lowest | 2 Average | 3 Highest |
| Program Outcomes | Level of Contribution | |
| 1) | Applies and develops the universal and social dimensional effects of basic, professional and technological knowledge in the field of pharmacy as well as pharmacy practice interdisciplinary by following legal, deontological and ethical rules. | 3 |
| 2) | Defines the terminology related to the pharmacy profession; solves problems , accesses scientific information in the field of pharmacy, after monitoring and evaluating the current literature, applies , communicates, shares by using information technologies effectively and efficiently. | 2 |
| 3) | Uses theoretical and practical knowledge about the anatomical structure of the human body, the physiological working principles of systems, biochemical, immunological events in the organism and microorganisms. | |
| 4) | Uses basic and advanced analytical techniques and methods by running qualitative/quantitative analyzes and interprets the findings by using appropriate statistical methods. | 3 |
| 5) | Defines medicinal plants, herbal drugs and active substances; gains the skills for the development of natural products used for medical purposes. | 1 |
| 6) | Applies patient-centered and individualized pharmaceutical care service together with other healthcare personnel within the framework of rational drug use by using the principles of clinical pharmacy, pharmacoeconomics, pharmacotherapy and phytotherapy. | 1 |
| 7) | Knows the biological properties, structure-activity relationships, and metabolisms of drugs and gains the skill for the synthesize and development of new drug candidates. | 3 |
| 8) | He/She is competent at formulations, production, stability, quality assurance, licensing, patent studies, legal regulations of products containing natural origin and / or synthetic active substances, advanced therapy medicinal products, radiopharmaceuticals and cosmetic products. | |
| 9) | Interprets the pharmacokinetic and pharmacodynamic properties of drugs, the factors that change their effect, their toxic effects, pharmacolygical activities and their risk assessment method. Reports the drug interactions and adverse drug reactions, monitors and applies the theoretical/practical knowledge for preventing them. | |
| 10) | As a health professional in his/her profession he/she acts as a caregiver, decision maker, communicator, manager, lifelong learner, instructor, leader and researcher, he/she complies with the principles of evidence-based pharmacy by making teamwork for the benefit of society, national and universal values. | 2 |
| 11) | He/She works in various fields such as community pharmacy, hospitals, pharmaceutical medical devices, herbal products and cosmetics sectors, health institutions and agencies, clinical research organizations , universities and R&D centers. | 2 |
Assessment & Grading
| Semester Requirements | Number of Activities | Level of Contribution |
| Midterms | 1 | % 30 |
| Final | 1 | % 70 |
| total | % 100 | |
| PERCENTAGE OF SEMESTER WORK | % 30 | |
| PERCENTAGE OF FINAL WORK | % 70 | |
| total | % 100 | |
Workload and ECTS Credit Calculation
| Activities | Number of Activities | Workload |
| Course Hours | 14 | 28 |
| Laboratory | 14 | 28 |
| Study Hours Out of Class | 14 | 14 |
| Midterms | 2 | 11 |
| Final | 2 | 16 |
| Total Workload | 97 | |