Molecular Biology and Genetics (English) Preview
Bachelor	TR-NQF-HE: Level 6	QF-EHEA: First Cycle	EQF-LLL: Level 6

Course Introduction and Application Information

Course Code:

MBG010

Course Name:

Protein Structure and Function

Semester:

Fall

Course Credits:

ECTS

Language of instruction:

English

Course Condition:

Does the Course Require Work Experience?:

Type of course:

Departmental Elective

Course Level:

Bachelor

TR-NQF-HE:6. Master`s Degree

QF-EHEA:First Cycle

EQF-LLL:6. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator:

Araş. Gör. KAAN ADACAN

Course Lecturer(s):

Dr. Öğr. Üy. ASLI KUTLU

Course Assistants:

Course Objective and Content

Course Objectives:

The objective of this course is to create a whole picture in people’s mind about the deep relationship between the structure and function of proteins. Here, we aim to introduce the fundamental basis for the essential things about the proteins’ function shaped by their finalized structure. The successful approaches for engineering the existed structure of proteins are introduced.

Course Content:

The content of this course is to provide a fundamental basis for structure and function of protein. Together with the introduction of thermodynamical basis for 3D structure, the essential roles of protein within systems are examined to relate structure more with its function. Moreover, several methods for engineering the protein structure for improving its existing enzymatic and kinetic features are introduced. The experimental approaches for identification of 3D structures of proteins are also introduced.

Learning Outcomes

The students who have succeeded in this course;
1) Learning the essential component of proteins
2) Gaining deep insight about the functions of proteins within different compartments of cells
3) Discovering the pathways driven by the existence of specific proteins
4) Providing the deep insight about how computational approaches could be integrated to elucidate the activation mechanism of proteins
5) Integrating the thermodynamic points of view about the structural basis of proteins

Course Flow Plan

Week	Subject	Related Preparation
1)	Introduction- The basis of protein translation
2)	Basic approaches to amino acids, peptide bonds and structure formations
3)	Motifs of protein structures
4)	Alpha-domain & Alpha/Beta Structures
5)	Antiparallel beta-structures
6)	DNA recognition by proteins
7)	Membrane proteins
8)	Midterm week
9)	Receptor families
10)	Determination of protein structures: X-RAY, NMR & CRYO- EM
11)	Engineering & Design of protein structures
12)	Engineering & Design of protein structures 2
13)	Case Study-Serine Proteases
14)	Presentations

Sources

Course Notes / Textbooks:	Introduction to Protein Structure, Carl Branden & John Tooze, Garland Publishing, 1991.
References:	Literatürde yer alan diğer ilgili yayınlar

Course - Program Learning Outcome Relationship

Course Learning Outcomes	1	2	3	4	5
Program Outcomes
1) Has a theoretical and practical background in biology, chemistry, physics and mathematics, which constitute the basic knowledge in the field of molecular biology and genetics.
2) Can explain biological phenomena and events at molecular level and relate them to other basic sciences and engineering applications.
3) Has the basic laboratory knowledge and skills required by the field.
4) Works in accordance with scientific principles and ethical rules.
5) Uses procedural and mathematical software programs required for the analysis and basic evaluation of biological data at least at the European Computer License Basic Level.
6) Has the knowledge, culture and skills to follow the literature and current methods related to his field.
7) Will be able to identify the main problem in line with the needs in health, agriculture, animal husbandry, environment, industry and similar issues and offer the necessary solutions by using up-to-date technology.
8) Has the knowledge and ability to evaluate biological phenomena and events at the level of systems from an evolutionary point of view.
9) Has the ability to be involved in individual and group work, to prepare and carry out projects on specific topics, and to make written and oral presentations.
10) Uses at least one foreign language in reading, writing and speaking at B1 General Level in terms of European Language Portfolio criteria.
11) Has the ability to identify social and global problems using his / her field knowledge and to be a part of the solution in interdisciplinary cooperation.
12) Respects social, cultural and individual differences, universal values and human rights in his / her scientific and professional activities.

Course - Learning Outcome Relationship

No Effect	1 Lowest	2 Average	3 Highest

	Program Outcomes	Level of Contribution
1)	Has a theoretical and practical background in biology, chemistry, physics and mathematics, which constitute the basic knowledge in the field of molecular biology and genetics.
2)	Can explain biological phenomena and events at molecular level and relate them to other basic sciences and engineering applications.
3)	Has the basic laboratory knowledge and skills required by the field.
4)	Works in accordance with scientific principles and ethical rules.
5)	Uses procedural and mathematical software programs required for the analysis and basic evaluation of biological data at least at the European Computer License Basic Level.
6)	Has the knowledge, culture and skills to follow the literature and current methods related to his field.
7)	Will be able to identify the main problem in line with the needs in health, agriculture, animal husbandry, environment, industry and similar issues and offer the necessary solutions by using up-to-date technology.
8)	Has the knowledge and ability to evaluate biological phenomena and events at the level of systems from an evolutionary point of view.
9)	Has the ability to be involved in individual and group work, to prepare and carry out projects on specific topics, and to make written and oral presentations.
10)	Uses at least one foreign language in reading, writing and speaking at B1 General Level in terms of European Language Portfolio criteria.
11)	Has the ability to identify social and global problems using his / her field knowledge and to be a part of the solution in interdisciplinary cooperation.
12)	Respects social, cultural and individual differences, universal values and human rights in his / her scientific and professional activities.

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Project	1	% 20
Midterms	1	% 30
Final	1	% 50
total		% 100
PERCENTAGE OF SEMESTER WORK		% 50
PERCENTAGE OF FINAL WORK		% 50
total		% 100

Workload and ECTS Credit Calculation

Activities	Number of Activities	Preparation for the Activity	Spent for the Activity Itself	Completing the Activity Requirements	Workload
Course Hours	13	0	3		39
Study Hours Out of Class	13	0	3		39
Project	1	0	10		10
Midterms	1	0	10		10
Final	1	0	20		20
Total Workload					118