| Cancer Biology and Pharmacology (Master) (with Thesis) | |||||
| Master | TR-NQF-HE: Level 7 | QF-EHEA: Second Cycle | EQF-LLL: Level 7 | ||
| Course Code: | KBY5113 | ||||
| Course Name: | Cancer Biology and Genetics | ||||
| Semester: | Fall | ||||
| Course Credits: |
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| Language of instruction: | Turkish | ||||
| Course Condition: | |||||
| Does the Course Require Work Experience?: | No | ||||
| Type of course: | Compulsory Courses | ||||
| Course Level: |
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| Mode of Delivery: | Face to face | ||||
| Course Coordinator: | Dr. Öğr. Üy. ÖYKÜ GÖNÜL GEYİK | ||||
| Course Lecturer(s): | Öykü GÖNÜL GEYİK, Yelda KUDU | ||||
| Course Assistants: |
| Course Objectives: | The aim of this course for each student; to learn the structure and pathology of cancer cells at molecular and genetic level. |
| Course Content: | Molecular and genetic mechanisms in cancer. |
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The students who have succeeded in this course;
1) Counts the causes of cancer development and explains its evolutionary importance. 2) Counts signaling pathways associated with growth factors and hormones involved in tumor development. 3) Explains cell cycle control mechanisms in cancer. 4) Explains the mechanisms of cancer cell death. 5) Discusses cancer metabolism by comparing it with physiological metabolism. 6) Defines the concepts of invasion, metastasis and angiogenesis and explains their importance in cancer. 7) Explain the importance of cancer microenvironment and immunology. 8) Counts DNA repair mechanisms and explains genome integrity. 9) Discusses the importance of genetic instability in cancer. 10) Explains the changes in epigenetic regulations in cancer. 11) Explains the roles of viruses, chemicals and radiation in carcinogenesis. 12) Defines oncogenesis and tumor suppression. 13) Discusses the effect and importance of telomerase regulation and immortalization in cancer. 14) Discusses the place of molecular studies in cancer research and their importance for the development of personalized medicine. |
| Week | Subject | Related Preparation |
| 1) | Cancer in the multicellular organism and evolutionary point of view | |
| 2) | Signaling pathways associated with growth factors and hormones involved in tumor development | |
| 3) | Cell cycle control and cancer cell death in cancer | |
| 4) | Respiration, response to hypoxia and cancer metabolism in cancer cells | |
| 5) | Invasion, metastasis and angiogenesis | |
| 6) | Cancer microenvironment and immunology | |
| 7) | Student presentations | |
| 8) | DNA repair and genome integration | |
| 9) | Genetic instability in cancer | |
| 10) | Cancer epigenetics | |
| 11) | Oncogenesis and tumor suppression | |
| 12) | Telomerase and immortalization | |
| 13) | Molecular profiling and personalized medicine in cancer research | |
| 14) | Final |
| Course Notes / Textbooks: | - Goodman's Medical Cell Biology, Academic Press, 2020 - Campbell Biology 10th Edition, Pearson, 2014 - William S. Klug, Michael R. Cummings, Concepts of Genetics, 11th edition, Pearson, 2014 - Cooper, G.M. The Cell: A Molecular Approach 8e, Oxford University Press, 2018 |
| References: | - Goodman's Medical Cell Biology, Academic Press, 2020 - Campbell Biology 10th Edition, Pearson, 2014 - William S. Klug, Michael R. Cummings, Concepts of Genetics, 11th edition, Pearson, 2014 - Cooper, G.M. The Cell: A Molecular Approach 8e, Oxford University Press, 2018 |
| Course Learning Outcomes | 1 |
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| Program Outcomes | ||||||||||||||
| 1) The ability to define basic concepts of Cancer Biology and Pharmacology, get information objectively about the related field within the scope of the program | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
| 2) Having knowledge about the molecular mechanisms of cancer, learning the process of carcinogenesis at molecular level | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
| 3) Learning of pharmacology and anti-cancer drug development, screening and relevant molecular/cellular techniques (cytotoxicity, etc.), get information about the postgraduate regulation related to cancer research and drug development, cooperation and experience share with institutions providing technological support | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| 4) The ability to synthesize, analyze, interpret, interrogate and criticize the relevant information on cancer biology and drug development | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
| 5) The ability to use good communication skills and computer technology efficiently in their work | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 6) The ability to convey/present the findings of the research and the results either verbally or in writing | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| 7) The ability to carry out professional and academic studies independently using accumulated knowledge and to work and take responsibility as a team member with other professions working in this field | ||||||||||||||
| 8) Having a sense of ethical responsibility in research | ||||||||||||||
| No Effect | 1 Lowest | 2 Average | 3 Highest |
| Program Outcomes | Level of Contribution | |
| 1) | The ability to define basic concepts of Cancer Biology and Pharmacology, get information objectively about the related field within the scope of the program | 3 |
| 2) | Having knowledge about the molecular mechanisms of cancer, learning the process of carcinogenesis at molecular level | 3 |
| 3) | Learning of pharmacology and anti-cancer drug development, screening and relevant molecular/cellular techniques (cytotoxicity, etc.), get information about the postgraduate regulation related to cancer research and drug development, cooperation and experience share with institutions providing technological support | 2 |
| 4) | The ability to synthesize, analyze, interpret, interrogate and criticize the relevant information on cancer biology and drug development | 3 |
| 5) | The ability to use good communication skills and computer technology efficiently in their work | 1 |
| 6) | The ability to convey/present the findings of the research and the results either verbally or in writing | 2 |
| 7) | The ability to carry out professional and academic studies independently using accumulated knowledge and to work and take responsibility as a team member with other professions working in this field | |
| 8) | Having a sense of ethical responsibility in research |
| Semester Requirements | Number of Activities | Level of Contribution |
| Midterms | 1 | % 50 |
| Final | 1 | % 50 |
| total | % 100 | |
| PERCENTAGE OF SEMESTER WORK | % 50 | |
| PERCENTAGE OF FINAL WORK | % 50 | |
| total | % 100 | |
| Activities | Number of Activities | Preparation for the Activity | Spent for the Activity Itself | Completing the Activity Requirements | Workload | ||
| Course Hours | 4 | 4 | 4 | 32 | |||
| Study Hours Out of Class | 10 | 0 | 10 | 100 | |||
| Presentations / Seminar | 6 | 6 | 1 | 42 | |||
| Homework Assignments | 2 | 0 | 6 | 12 | |||
| Midterms | 1 | 6 | 1 | 7 | |||
| Final | 1 | 6 | 1 | 7 | |||
| Total Workload | 200 | ||||||