| Cancer Biology and Pharmacology (Master) (with Thesis) | |||||
| Master | TR-NQF-HE: Level 7 | QF-EHEA: Second Cycle | EQF-LLL: Level 7 | ||
| Course Code: | KBY5104 | ||||
| Course Name: | Cancer Pharmacology | ||||
| Semester: | Spring | ||||
| Course Credits: |
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| Language of instruction: | Turkish | ||||
| Course Condition: | |||||
| Does the Course Require Work Experience?: | No | ||||
| Type of course: | Compulsory Courses | ||||
| Course Level: |
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| Mode of Delivery: | |||||
| Course Coordinator: | Prof. Dr. YUSUF SARIOĞLU | ||||
| Course Lecturer(s): |
Prof. Dr. YUSUF SARIOĞLU |
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| Course Assistants: |
| Course Objectives: | Understanding the basic principles of pharmacology, learning, basic information about pharmacokinetics and pharmacodynamics, and mechanisms of drug action Evaluating the working principles of the autonomic nervous system from a pharmacological point of view, learning basic information about drugs effective on the system To inform about the targets of cancer chemotherapy, resistance mechanisms for cancer drugs, and prevention of chemotherapy-induced toxicity |
| Course Content: | General pharmacology concepts; absorption, distribution, excretion and detoxification mechanisms; features of the autonomic nervous system, neurotransmitters, drugs used in some diseases and their mechanisms of action; Drugs used in cancer treatment, their mechanism of action and adverse effects |
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The students who have succeeded in this course;
1) Learns the basic concepts of drug effect in the clinic and can comprehend the principles and criteria of rational drug use. 2) Explain the general concepts related to the pharmacokinetic and pharmacodynamic properties of drugs 3) Understands the mechanisms of action of drugs and can explain the concentration-effect relationships 4) Explain the basic concepts of drug interactions that can occur as a pharmacokinetic and pharmacodynamic interaction 5) Evaluate the working principles of the autonomic nervous system from a pharmacological point of view, and comprehend the basic information about drugs that affect this system 5) Explain the mechanism of action of antineoplastic drugs 6) Explain the important points of pharmacokinetic principles related with antineoplastic drugs 7) Explain the resistance mechanisms of antineoplastic drugs 8) List the adverse effects of antineoplastic drugs |
| Week | Subject | Related Preparation |
| 1) | Introduction to Pharmacology and Basic Concepts | |
| 2) | Pharmaceutical Forms of Drugs and Routes of Drug Administration | |
| 3) | Pharmacokinetic Properties; Absorption of Drugs, Biotransformation of Drugs | |
| 4) | Distribution and Elimination of Drugs | |
| 5) | Pharmacodynamic Properties; Dose-Concentration-Effect Relationship, Dosage Calculation in Drugs, Mechanisms of Action of Drugs | |
| 6) | Drug-Receptor Relationship, Factors Affecting Drug Action | |
| 7) | Drug Interactions; Toxic Effects of Drugs, Rational Drug Use | |
| 8) | Midterm Exam | |
| 9) | Drugs That Effect on the Autonomic Nervous System | |
| 10) | Effects of Sympathetic and Parasympathetic System | |
| 11) | Basic Information and Concepts of Cancer Chemotherapy | |
| 12) | Fundamentals of Cancer Chemotherapy and Antineoplastic Drugs | |
| 13) | Antineoplastic Drugs I | |
| 14) | Antineoplastic Drugs II | |
| 15) | Immunomodulatory Drugs | |
| 16) | Homework Submission and Listening to Presentations |
| Course Notes / Textbooks: | Kayaalp, O. (2012). Rasyonel Tedavi Yönünden Tıbbi Farmakoloji (13’üncü baskı). Ankara: Pelikan Tıp Teknik Yayıncılık. Katzung, B.G. (2020). Basic and Clinical Pharmacology (15th edition). USA: McGraw-Hill Companies. |
| References: | Alana özgü kaynak farmakoloji kitapları ve literatür bilgisi Kayaalp, O. (2012). Rasyonel Tedavi Yönünden Tıbbi Farmakoloji (13’üncü baskı). Ankara: Pelikan Tıp Teknik Yayıncılık. Brunton, L., Knollman, B., Hilal-Dandan, R. (2021). Goodman and Gilman s The Pharmacological Basis of Therapeutics (14th edition). USA: McGraw and Hill Company. Whalen, K., Radhakrishnan, R., Felid, K.(2018). Lippincott s Illustrated Reviews: Pharmacology (7th edition). USA: Lippincott Williams & Wilkins. Katzung, B.G. (2020). Basic and Clinical Pharmacology (15th edition). USA: McGraw-Hill Companies. • Trevor, A.J., Masters S.B. , Katzung B.G. (2019). Çeviri Editörü: Erden, B.F. Katzung ve Trevor Farmakoloji - Sınav ve Gözden Geçirme (14’inci baskı). USA: McGraw-Hill Companies |
| Course Learning Outcomes | 1 |
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7 |
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| Program Outcomes | |||||||||
| 1) The ability to define basic concepts of Cancer Biology and Pharmacology, get information objectively about the related field within the scope of the program | |||||||||
| 2) Having knowledge about the molecular mechanisms of cancer, learning the process of carcinogenesis at molecular level | |||||||||
| 3) Learning of pharmacology and anti-cancer drug development, screening and relevant molecular/cellular techniques (cytotoxicity, etc.), get information about the postgraduate regulation related to cancer research and drug development, cooperation and experience share with institutions providing technological support | |||||||||
| 4) The ability to synthesize, analyze, interpret, interrogate and criticize the relevant information on cancer biology and drug development | |||||||||
| 5) The ability to use good communication skills and computer technology efficiently in their work | |||||||||
| 6) The ability to convey/present the findings of the research and the results either verbally or in writing | |||||||||
| 7) The ability to carry out professional and academic studies independently using accumulated knowledge and to work and take responsibility as a team member with other professions working in this field | |||||||||
| 8) Having a sense of ethical responsibility in research | |||||||||
| No Effect | 1 Lowest | 2 Average | 3 Highest |
| Program Outcomes | Level of Contribution | |
| 1) | The ability to define basic concepts of Cancer Biology and Pharmacology, get information objectively about the related field within the scope of the program | |
| 2) | Having knowledge about the molecular mechanisms of cancer, learning the process of carcinogenesis at molecular level | |
| 3) | Learning of pharmacology and anti-cancer drug development, screening and relevant molecular/cellular techniques (cytotoxicity, etc.), get information about the postgraduate regulation related to cancer research and drug development, cooperation and experience share with institutions providing technological support | |
| 4) | The ability to synthesize, analyze, interpret, interrogate and criticize the relevant information on cancer biology and drug development | |
| 5) | The ability to use good communication skills and computer technology efficiently in their work | |
| 6) | The ability to convey/present the findings of the research and the results either verbally or in writing | |
| 7) | The ability to carry out professional and academic studies independently using accumulated knowledge and to work and take responsibility as a team member with other professions working in this field | |
| 8) | Having a sense of ethical responsibility in research |
| Semester Requirements | Number of Activities | Level of Contribution |
| Quizzes | 1 | % 5 |
| Homework Assignments | 1 | % 20 |
| Presentation | 1 | % 5 |
| Midterms | 1 | % 30 |
| Final | 1 | % 40 |
| total | % 100 | |
| PERCENTAGE OF SEMESTER WORK | % 60 | |
| PERCENTAGE OF FINAL WORK | % 40 | |
| total | % 100 | |
| Activities | Number of Activities | Workload |
| Course Hours | 16 | 32 |
| Study Hours Out of Class | 16 | 32 |
| Presentations / Seminar | 16 | 16 |
| Project | 2 | 4 |
| Homework Assignments | 16 | 16 |
| Quizzes | 16 | 16 |
| Midterms | 1 | 1 |
| Final | 1 | 1 |
| Total Workload | 118 | |