ISTINYE UNIVERSITY BİLGİ PAKETİ / DERS KATALOĞU
| Pharmacy (English) | |||||
| Bachelor | TR-NQF-HE: Level 6 | QF-EHEA: First Cycle | EQF-LLL: Level 6 | ||
Course Introduction and Application Information
| Course Code: | PHA206 | ||||
| Course Name: | Clinical Biochemistry | ||||
| Semester: | Spring | ||||
| Course Credits: |
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| Language of instruction: | English | ||||
| Course Condition: | |||||
| Does the Course Require Work Experience?: | No | ||||
| Type of course: | Compulsory Courses | ||||
| Course Level: |
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| Mode of Delivery: | E-Learning | ||||
| Course Coordinator: | Dr. Öğr. Üy. ELİF YAVUZ DOKGÖZ | ||||
| Course Lecturer(s): | Prof. Dr. Abdullah Olgun | ||||
| Course Assistants: |
Course Objective and Content
| Course Objectives: | Clinical laboratory plays an integrated role in the diagnosis, prognosis, treatment and long-term management of disease. Proper selection and interpretation of laboratory tests is critical for quality of patient care. In the last few decades, there has been an information explosion in the field of laboratory medicine, making it difficult for health care professionals to remain fluent in all aspects of laboratory testing. It has been said that 80% of all medical decisions encompass clinical laboratory data in the decision process. This course and laboratory aims to enable students to deeply understand; preanalytical, analytical and postanalytical phases of laboratory testing process both theoretically and by laboratory practices, commonly used diagnostic tests and diagnostic approaches to common disease states and how to interpret laboratory tests. |
| Course Content: | This course covers basic clinical biochemistry topics including preanalytical, analytical and postanalytical phases of laboratory testing process, analysis of blood cells, chemical analysis of blood plasma contents, coagulation, hormones, viral and tumor markers, therapeutic drug monitoring, urinalysis, rational interpretation and evaluation of laboratory results. |
Learning Outcomes
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The students who have succeeded in this course;
1) Explain the basics of clinical biochemistry. 2) Discuss the different phases of laboratory testing process. 3) Considers different phases of laboratory testing process when interpreting laboratory tests. 4) Assess clinical biochemical data for diagnosis, screening and treatment of various diseases. 5) Explain the relationship between biochemistry and diseases, use this knowledge in patient-centered pharmaceutical applications. 6) Interpret laboratory results. 7) Use their skills such as communication (written and verbal) and group-work. |
Course Flow Plan
| Week | Subject | Related Preparation |
| 1) | T: Overview of the course; Introduction to clinical biochemistry P: Introduction to Evidence-Based Laboratory Medicine - TRIP database (Online) https://www.tripdatabase.com/ | https://www.tripdatabase.com/ |
| 1) | ||
| 2) | T: Preanalytical Phase in clinical laboratory testing process P: Preanalytical phase pplications (Online) | Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition |
| 3) | T: Analytical Phase in clinical laboratory testing process U: Blood tubes, other sample containers, centrifuge; Hematocrit and Sedimentation (ESR) tests, Peripheral smear preparation (Face to face) | Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition |
| 4) | T: Postanalytical Phase in clinical laboratory testing process P: Reference Interval Calculation (Online) | Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition |
| 5) | T: Blood Cell Analysis P: Blood smear examination and tube distribution for FOBT (Face to face) | Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition |
| 6) | T: Blood Biochemistry: Minerals, Metabolites and Glucose Homeostasis P: Glucometer (rubric) (Online) | Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition |
| 7) | T: Blood Biochemistry: Enzymes P: Glucometer, FOBT and LDH measurement (Face to face) | Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition |
| 8) | T: Blood Biochemistry: Proteins Midterm Exam (Theoretical) P: Enzyme activity calculation and Electrophoresis (Online) | Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition |
| 9) | T: Blood Biochemistry: Lipids P: Interpretation of Laboratory Tests - I (Online) | Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition |
| 10) | T: Urinalysis P: Urinalysis (Face to face) | Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition |
| 11) | T: Coagulation P: INR (rubric) (Online) | Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition |
| 12) | T: Hormones and Tumor Markers P: Evidence Based Guidelines (Online) | Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition |
| 13) | T: Viral Markers U: Interpretation of Laboratory Tests (II) (Online) | Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition |
| 14) | T: Therapeutic Drug Monitoring (TDM); U: Hospital Laboratory Visit (Face to face) | Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition |
| 15) | FINAL EXAM | Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition |
Sources
| Course Notes / Textbooks: | 1. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition By Carl A. Burtis, PhD, Edward R. Ashwood, MD and David E. Bruns, MD (2018) 2. Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 7th Edition (2015) 3. Henry's Clinical Diagnosis and Management by Laboratory Methods, 23rd Edition 4. Pocket Guide to Diagnostic Tests, 6th Ed Diana Nicoll, Chuanyi Mark Lu, Michael Pignone, Stephen J. McPhee 5. Analytical techniques for clinical chemistry : methods and applications /edited by Sergio Caroli, Gyula Za´ray. (2012) 6. Tietz's Applied Laboratory Medicine by Mitchell G. Scott, 2nd Ed. 2007 |
| References: | 1. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition By Carl A. Burtis, PhD, Edward R. Ashwood, MD and David E. Bruns, MD (2018) 2. Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 7th Edition (2015) 3. Henry's Clinical Diagnosis and Management by Laboratory Methods, 23rd Edition 4. Pocket Guide to Diagnostic Tests, 6th Ed Diana Nicoll, Chuanyi Mark Lu, Michael Pignone, Stephen J. McPhee 5. Analytical techniques for clinical chemistry : methods and applications /edited by Sergio Caroli, Gyula Za´ray. (2012) 6. Tietz's Applied Laboratory Medicine by Mitchell G. Scott, 2nd Ed. 2007 |
Course - Program Learning Outcome Relationship
| Course Learning Outcomes | 1 |
2 |
3 |
4 |
5 |
6 |
7 |
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|---|---|---|---|---|---|---|---|---|---|---|---|
| Program Outcomes | |||||||||||
| 1) Applies and develops the universal and social dimensional effects of basic, professional and technological knowledge in the field of pharmacy as well as pharmacy practice interdisciplinary by following legal, deontological and ethical rules. | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||
| 2) Defines the terminology related to the pharmacy profession; solves problems , accesses scientific information in the field of pharmacy, after monitoring and evaluating the current literature, applies , communicates, shares by using information technologies effectively and efficiently. | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||
| 3) Uses theoretical and practical knowledge about the anatomical structure of the human body, the physiological working principles of systems, biochemical, immunological events in the organism and microorganisms. | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||
| 4) Uses basic and advanced analytical techniques and methods by running qualitative/quantitative analyzes and interprets the findings by using appropriate statistical methods. | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||
| 5) Defines medicinal plants, herbal drugs and active substances; gains the skills for the development of natural products used for medical purposes. | |||||||||||
| 6) Applies patient-centered and individualized pharmaceutical care service together with other healthcare personnel within the framework of rational drug use by using the principles of clinical pharmacy, pharmacoeconomics, pharmacotherapy and phytotherapy. | |||||||||||
| 7) Knows the biological properties, structure-activity relationships, and metabolisms of drugs and gains the skill for the synthesize and development of new drug candidates. | |||||||||||
| 8) He/She is competent at formulations, production, stability, quality assurance, licensing, patent studies, legal regulations of products containing natural origin and / or synthetic active substances, advanced therapy medicinal products, radiopharmaceuticals and cosmetic products. | |||||||||||
| 9) Interprets the pharmacokinetic and pharmacodynamic properties of drugs, the factors that change their effect, their toxic effects, pharmacolygical activities and their risk assessment method. Reports the drug interactions and adverse drug reactions, monitors and applies the theoretical/practical knowledge for preventing them. | |||||||||||
| 10) As a health professional in his/her profession he/she acts as a caregiver, decision maker, communicator, manager, lifelong learner, instructor, leader and researcher, he/she complies with the principles of evidence-based pharmacy by making teamwork for the benefit of society, national and universal values. | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||
| 11) He/She works in various fields such as community pharmacy, hospitals, pharmaceutical medical devices, herbal products and cosmetics sectors, health institutions and agencies, clinical research organizations , universities and R&D centers. | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||
Course - Learning Outcome Relationship
| No Effect | 1 Lowest | 2 Average | 3 Highest |
| Program Outcomes | Level of Contribution | |
| 1) | Applies and develops the universal and social dimensional effects of basic, professional and technological knowledge in the field of pharmacy as well as pharmacy practice interdisciplinary by following legal, deontological and ethical rules. | 1 |
| 2) | Defines the terminology related to the pharmacy profession; solves problems , accesses scientific information in the field of pharmacy, after monitoring and evaluating the current literature, applies , communicates, shares by using information technologies effectively and efficiently. | 2 |
| 3) | Uses theoretical and practical knowledge about the anatomical structure of the human body, the physiological working principles of systems, biochemical, immunological events in the organism and microorganisms. | 3 |
| 4) | Uses basic and advanced analytical techniques and methods by running qualitative/quantitative analyzes and interprets the findings by using appropriate statistical methods. | 3 |
| 5) | Defines medicinal plants, herbal drugs and active substances; gains the skills for the development of natural products used for medical purposes. | |
| 6) | Applies patient-centered and individualized pharmaceutical care service together with other healthcare personnel within the framework of rational drug use by using the principles of clinical pharmacy, pharmacoeconomics, pharmacotherapy and phytotherapy. | |
| 7) | Knows the biological properties, structure-activity relationships, and metabolisms of drugs and gains the skill for the synthesize and development of new drug candidates. | |
| 8) | He/She is competent at formulations, production, stability, quality assurance, licensing, patent studies, legal regulations of products containing natural origin and / or synthetic active substances, advanced therapy medicinal products, radiopharmaceuticals and cosmetic products. | |
| 9) | Interprets the pharmacokinetic and pharmacodynamic properties of drugs, the factors that change their effect, their toxic effects, pharmacolygical activities and their risk assessment method. Reports the drug interactions and adverse drug reactions, monitors and applies the theoretical/practical knowledge for preventing them. | |
| 10) | As a health professional in his/her profession he/she acts as a caregiver, decision maker, communicator, manager, lifelong learner, instructor, leader and researcher, he/she complies with the principles of evidence-based pharmacy by making teamwork for the benefit of society, national and universal values. | 3 |
| 11) | He/She works in various fields such as community pharmacy, hospitals, pharmaceutical medical devices, herbal products and cosmetics sectors, health institutions and agencies, clinical research organizations , universities and R&D centers. | 3 |
Assessment & Grading
| Semester Requirements | Number of Activities | Level of Contribution |
| Application | 8 | % 15 |
| Midterms | 1 | % 15 |
| Final | 1 | % 70 |
| total | % 100 | |
| PERCENTAGE OF SEMESTER WORK | % 30 | |
| PERCENTAGE OF FINAL WORK | % 70 | |
| total | % 100 | |
Workload and ECTS Credit Calculation
| Activities | Number of Activities | Workload |
| Course Hours | 14 | 14 |
| Laboratory | 14 | 28 |
| Study Hours Out of Class | 14 | 28 |
| Quizzes | 14 | 14 |
| Midterms | 1 | 1 |
| Final | 1 | 1 |
| Total Workload | 86 | |