ISTINYE UNIVERSITY BİLGİ PAKETİ / DERS KATALOĞU
| Pharmacy | |||||
| Bachelor | TR-NQF-HE: Level 6 | QF-EHEA: First Cycle | EQF-LLL: Level 6 | ||
Course Introduction and Application Information
| Course Code: | ECZ405 | ||||
| Course Name: | General Toxicology | ||||
| Semester: | Fall | ||||
| Course Credits: |
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| Language of instruction: | Turkish | ||||
| Course Condition: | |||||
| Does the Course Require Work Experience?: | No | ||||
| Type of course: | Compulsory Courses | ||||
| Course Level: |
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| Mode of Delivery: | Face to face | ||||
| Course Coordinator: | Prof. Dr. SEMRA ŞARDAŞ | ||||
| Course Lecturer(s): | PROF. DR. SEMRA ŞARDAŞ | ||||
| Course Assistants: |
Course Objective and Content
| Course Objectives: | It aims to give the Basic concepts of toxicology to Faculty of Pharmacy students; factors affecting toxicity; the fate of xenobiotics in the body; It aims to provide students with sufficient theoretical knowledge about the general principles and application areas of toxicology about the damages of drugs and chemical, biological and physical factors to the biological system and the investigation of these damages at the macro and molecular level, and the change in response to drugs due to genetic factors. |
| Course Content: | The content of the course includes Dose, Lethal Dose, LD50, Therapeutic Index, Minimum Therapeutic Dose, Entry Routes of Poisons into the Body, Toxicity studies (Acute, Subacute, Chronic intoxication), dose-response relationship, Absorption, Distribution, Metabolism, Excretion, factors and mechanisms affecting toxicity, biotransformation reactions and toxicity relationship; carcinogenesis; mutation, teratogenesis, and genetic toxicology. |
Learning Outcomes
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The students who have succeeded in this course;
1) Knows toxicity mechanisms. 2) Evaluates the metabolism of drug substance. 3) Evaluates the product for toxicity and patient safety. 4) Learns concepts such as chemical carcinogens, mutagen agents, teratogenesis mechanism, Pharmacogenomics, Proteomics, Metabolomics. |
Course Flow Plan
| Week | Subject | Related Preparation |
| 1) | Principle of Toxicology | |
| 2) | Toxicity Mechanisms | |
| 3) | Metabolism of Toxic Substances (Biotransformation) | |
| 4) | Individual factors affecting toxicity in biotransformation I | |
| 5) | Individual factors affecting toxicity in biotransformation II | |
| 6) | Pharmacogenomics, Toxicogenomics | |
| 7) | Toxic Effects Due to Genetic Factors I | |
| 8) | Fall Semester Midterm Period | |
| 9) | Toxic Effects Due to Genetic Factors II | |
| 10) | Toxic Effect / Adverse Effect, Side Effect mechanisms | |
| 11) | Genetic Toxicology I | |
| 12) | Genetic Toxicology II | |
| 13) | Chemical Carcinogenesis | |
| 14) | Teratogenesis | |
| 15) | Fall Semester Final Exam Period |
Sources
| Course Notes / Textbooks: | Casarett & Doull's Toxicology: The basic science of poisons Klaassen CD, Amdur MO,Doull J; (3rd Ed, 1986) Macmillan Publishing |
| References: | Principles of Toxicology: Environmental and Industrial Applications, 3rd Edition,2015 Stephen M. Roberts, Robert C. James, Phillip L. Williams (Editors) Occupational Toxicology Edited By Chris Winder, Neill H. Stacey 2019 by CRC Press |
Course - Program Learning Outcome Relationship
| Course Learning Outcomes | 1 |
2 |
3 |
4 |
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|---|---|---|---|---|---|---|---|---|---|---|---|
| Program Outcomes | |||||||||||
| 1) Applies and develops the universal and social dimensional effects of basic, professional and technological knowledge in the field of pharmacy as well as pharmacy practice interdisciplinary by following legal, deontological and ethical rules. | 3 | 3 | 3 | 3 | |||||||
| 2) Defines the terminology related to the pharmacy profession; solves problems , accesses scientific information in the field of pharmacy, after monitoring and evaluating the current literature, applies , communicates, shares by using information technologies effectively and efficiently. | 2 | 2 | 2 | 2 | |||||||
| 3) Uses theoretical and practical knowledge about the anatomical structure of the human body, the physiological working principles of systems, biochemical, immunological events in the organism and microorganisms. | |||||||||||
| 4) Uses basic and advanced analytical techniques and methods by running qualitative/quantitative analyzes and interprets the findings by using appropriate statistical methods. | 2 | 1 | |||||||||
| 5) Defines medicinal plants, herbal drugs and active substances; gains the skills for the development of natural products used for medical purposes. | |||||||||||
| 6) Applies patient-centered and individualized pharmaceutical care service together with other healthcare personnel within the framework of rational drug use by using the principles of clinical pharmacy, pharmacoeconomics, pharmacotherapy and phytotherapy. | 3 | 3 | 3 | 3 | |||||||
| 7) Knows the biological properties, structure-activity relationships, and metabolisms of drugs and gains the skill for the synthesize and development of new drug candidates. | 2 | 3 | 2 | 2 | |||||||
| 8) He/She is competent at formulations, production, stability, quality assurance, licensing, patent studies, legal regulations of products containing natural origin and / or synthetic active substances, advanced therapy medicinal products, radiopharmaceuticals and cosmetic products. | |||||||||||
| 9) Interprets the pharmacokinetic and pharmacodynamic properties of drugs, the factors that change their effect, their toxic effects, pharmacolygical activities and their risk assessment method. Reports the drug interactions and adverse drug reactions, monitors and applies the theoretical/practical knowledge for preventing them. | 3 | 3 | 3 | 3 | |||||||
| 10) As a health professional in his/her profession he/she acts as a caregiver, decision maker, communicator, manager, lifelong learner, instructor, leader and researcher, he/she complies with the principles of evidence-based pharmacy by making teamwork for the benefit of society, national and universal values. | 3 | 3 | 3 | 3 | |||||||
| 11) He/She works in various fields such as community pharmacy, hospitals, pharmaceutical medical devices, herbal products and cosmetics sectors, health institutions and agencies, clinical research organizations , universities and R&D centers. | 3 | 3 | 3 | 3 | |||||||
Course - Learning Outcome Relationship
| No Effect | 1 Lowest | 2 Average | 3 Highest |
| Program Outcomes | Level of Contribution | |
| 1) | Applies and develops the universal and social dimensional effects of basic, professional and technological knowledge in the field of pharmacy as well as pharmacy practice interdisciplinary by following legal, deontological and ethical rules. | 3 |
| 2) | Defines the terminology related to the pharmacy profession; solves problems , accesses scientific information in the field of pharmacy, after monitoring and evaluating the current literature, applies , communicates, shares by using information technologies effectively and efficiently. | 2 |
| 3) | Uses theoretical and practical knowledge about the anatomical structure of the human body, the physiological working principles of systems, biochemical, immunological events in the organism and microorganisms. | |
| 4) | Uses basic and advanced analytical techniques and methods by running qualitative/quantitative analyzes and interprets the findings by using appropriate statistical methods. | 2 |
| 5) | Defines medicinal plants, herbal drugs and active substances; gains the skills for the development of natural products used for medical purposes. | |
| 6) | Applies patient-centered and individualized pharmaceutical care service together with other healthcare personnel within the framework of rational drug use by using the principles of clinical pharmacy, pharmacoeconomics, pharmacotherapy and phytotherapy. | 3 |
| 7) | Knows the biological properties, structure-activity relationships, and metabolisms of drugs and gains the skill for the synthesize and development of new drug candidates. | 2 |
| 8) | He/She is competent at formulations, production, stability, quality assurance, licensing, patent studies, legal regulations of products containing natural origin and / or synthetic active substances, advanced therapy medicinal products, radiopharmaceuticals and cosmetic products. | |
| 9) | Interprets the pharmacokinetic and pharmacodynamic properties of drugs, the factors that change their effect, their toxic effects, pharmacolygical activities and their risk assessment method. Reports the drug interactions and adverse drug reactions, monitors and applies the theoretical/practical knowledge for preventing them. | 3 |
| 10) | As a health professional in his/her profession he/she acts as a caregiver, decision maker, communicator, manager, lifelong learner, instructor, leader and researcher, he/she complies with the principles of evidence-based pharmacy by making teamwork for the benefit of society, national and universal values. | 3 |
| 11) | He/She works in various fields such as community pharmacy, hospitals, pharmaceutical medical devices, herbal products and cosmetics sectors, health institutions and agencies, clinical research organizations , universities and R&D centers. | 3 |
Assessment & Grading
| Semester Requirements | Number of Activities | Level of Contribution |
| Midterms | 1 | % 30 |
| Final | 1 | % 70 |
| total | % 100 | |
| PERCENTAGE OF SEMESTER WORK | % 30 | |
| PERCENTAGE OF FINAL WORK | % 70 | |
| total | % 100 | |
Workload and ECTS Credit Calculation
| Activities | Number of Activities | Workload |
| Course Hours | 14 | 42 |
| Study Hours Out of Class | 14 | 65 |
| Midterms | 1 | 2 |
| Final | 1 | 2 |
| Total Workload | 111 | |