ECZ301 Pharmaceutical Chemistry 1Istinye UniversityDegree Programs PharmacyGeneral Information For StudentsDiploma SupplementErasmus Policy StatementNational Qualifications
Pharmacy

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Bachelor TR-NQF-HE: Level 6 QF-EHEA: First Cycle EQF-LLL: Level 6

Course Introduction and Application Information

Course Code: ECZ301
Course Name: Pharmaceutical Chemistry 1
Semester: Fall
Course Credits:
ECTS
6
Language of instruction: Turkish
Course Condition:
Does the Course Require Work Experience?: No
Type of course: Compulsory Courses
Course Level:
Bachelor TR-NQF-HE:6. Master`s Degree QF-EHEA:First Cycle EQF-LLL:6. Master`s Degree
Mode of Delivery: E-Learning
Course Coordinator: Dr. Öğr. Üy. ONUR ŞAHİN
Course Lecturer(s): Bedia Kaymakçıoğlu, Onur ŞAHİN
Course Assistants:

Course Objective and Content

Course Objectives: Aim of this course is to teach, design and synthesis of natural and synthetic origin pharmaceutical active ingredients used in diagnosis and treatment of Central nervous system disorders, and generally have an educational concept of to teach the basic concepts of medicinal chemistry and drug groups.
Course Content: In this course formula, nomenclature, general physicochemical properties, general synthetic pathways, metabolism, stability, general chemical analysis, structure-activity relationships of pharmaceutical active ingredients used in diagnosis and treatment of some diseases are given. Within this general topic introduction to medicinal chemistry, metabolism, structure-activity relationships, transport systems, chemical bonding, narcotic analgesics, non-steroidal anti-inflammatory drugs, sedative and hypnotic drugs, tranquilizing drugs, neuroleptics, anticancer drugs, general anesthetics, local anesthetics, antidepressants, myorelaxant drugs, anticonvulsants, antiepileptics, antihistamines are taught.

Learning Outcomes

The students who have succeeded in this course;
1) New drug discovery
2) Behavior forms of molecules entering the living body
3) Primary requirement of Pharmaceutical Chemistry in the Pharmaceutical Industry
4) Recognition of basic medicine-related sciences
5) Information about design, synthesis, analysis and metabolism of pharmaceutical products
6) Project development and presentation on pharmaceutical teamwork, research and development

Course Flow Plan

Week Subject Related Preparation
1) Teo: Introduction to Pharmaceutical and Medicinal Chemistry Lab: Discussion of the syllabus, Laboratory safety and first aid 1) Foye's Principles of Medicinal Chemistry, 7th Edition, by David A. Williams and Thomas L. Lemke, Lippincott Williams & Wilkins, 2013. 2) Wilson’s and Gisvold’s, Organic Medisinal and Pharmaceutical Chemistry, 12th Edition, John M. Beale, John H. Block, Walters Kluwer, 2011.
2) Teo: Metabolism, structure-activity relationships, Transport systems, Chemical Bonding Lab: Laboratory instruments and techniques 1) Foye's Principles of Medicinal Chemistry, 7th Edition, by David A. Williams and Thomas L. Lemke, Lippincott Williams & Wilkins, 2013. 2) Wilson’s and Gisvold’s, Organic Medisinal and Pharmaceutical Chemistry, 12th Edition, John M. Beale, John H. Block, Walters Kluwer, 2011
3) Teo: Antipsychotic Drugs – Narcotic Analgesics Lab: Extraction Method 1) Foye's Principles of Medicinal Chemistry, 7th Edition, by David A. Williams and Thomas L. Lemke, Lippincott Williams & Wilkins, 2013. 2) Wilson’s and Gisvold’s, Organic Medisinal and Pharmaceutical Chemistry, 12th Edition, John M. Beale, John H. Block, Walters Kluwer, 2011
4) Teo: Antihistaminic Drugs Lab: Extraction Experiment 1) Foye's Principles of Medicinal Chemistry, 7th Edition, by David A. Williams and Thomas L. Lemke, Lippincott Williams & Wilkins, 2013. 2) Wilson’s and Gisvold’s, Organic Medisinal and Pharmaceutical Chemistry, 12th Edition, John M. Beale, John H. Block, Walters Kluwer, 2011.
5) Teo: Non-Steroidal anti-inflammatory Drugs Sedative and Hypnotic Drugs Lab: Distillation 1) Foye's Principles of Medicinal Chemistry, 7th Edition, by David A. Williams and Thomas L. Lemke, Lippincott Williams & Wilkins, 2013. 2) Wilson’s and Gisvold’s, Organic Medisinal and Pharmaceutical Chemistry, 12th Edition, John M. Beale, John H. Block, Walters Kluwer, 2011.
6) Teo: Tranquilizer (Anxiolytic) Drugs Lab: Esterification 1) Foye's Principles of Medicinal Chemistry, 7th Edition, by David A. Williams and Thomas L. Lemke, Lippincott Williams & Wilkins, 2013. 2) Wilson’s and Gisvold’s, Organic Medisinal and Pharmaceutical Chemistry, 12th Edition, John M. Beale, John H. Block, Walters Kluwer, 2011.
7) Teo: Midterm Exam-1 Lab: Midterm Exam 1) Foye's Principles of Medicinal Chemistry, 7th Edition, by David A. Williams and Thomas L. Lemke, Lippincott Williams & Wilkins, 2013. 2) Wilson’s and Gisvold’s, Organic Medisinal and Pharmaceutical Chemistry, 12th Edition, John M. Beale, John H. Block, Walters Kluwer, 2011.
8) Teo: Sedative Hypnotic Medications Lab: Crystallization 1) Foye's Principles of Medicinal Chemistry, 7th Edition, by David A. Williams and Thomas L. Lemke, Lippincott Williams & Wilkins, 2013. 2) Wilson’s and Gisvold’s, Organic Medisinal and Pharmaceutical Chemistry, 12th Edition, John M. Beale, John H. Block, Walters Kluwer, 2011.
9) Teo: Antiepileptics Lab: Crystallization Experiment 1) Foye's Principles of Medicinal Chemistry, 7th Edition, by David A. Williams and Thomas L. Lemke, Lippincott Williams & Wilkins, 2013. 2) Wilson’s and Gisvold’s, Organic Medisinal and Pharmaceutical Chemistry, 12th Edition, John M. Beale, John H. Block, Walters Kluwer, 2011.
10) Teo: Local Anesthetic Drugs Lab: Separation and purification Methods 1 Thin Layer Chromatography 1) Foye's Principles of Medicinal Chemistry, 7th Edition, by David A. Williams and Thomas L. Lemke, Lippincott Williams & Wilkins, 2013. 2) Wilson’s and Gisvold’s, Organic Medisinal and Pharmaceutical Chemistry, 12th Edition, John M. Beale, John H. Block, Walters Kluwer, 2011.
11) Teo: General anesthetics Lab: Thin Layer Chromatography experiment 1) Foye's Principles of Medicinal Chemistry, 7th Edition, by David A. Williams and Thomas L. Lemke, Lippincott Williams & Wilkins, 2013. 2) Wilson’s and Gisvold’s, Organic Medisinal and Pharmaceutical Chemistry, 12th Edition, John M. Beale, John H. Block, Walters Kluwer, 2011.
12) Teo: Narcotic Analgesic Drugs Lab: Separation and purification Methods 2 Column chromatography 1) Foye's Principles of Medicinal Chemistry, 7th Edition, by David A. Williams and Thomas L. Lemke, Lippincott Williams & Wilkins, 2013. 2) Wilson’s and Gisvold’s, Organic Medisinal and Pharmaceutical Chemistry, 12th Edition, John M. Beale, John H. Block, Walters Kluwer, 2011.
13) Teo: Myorelaxant Drugs Lab: Molecular descriptors, physicochemical parameters 1) Foye's Principles of Medicinal Chemistry, 7th Edition, by David A. Williams and Thomas L. Lemke, Lippincott Williams & Wilkins, 2013. 2) Wilson’s and Gisvold’s, Organic Medisinal and Pharmaceutical Chemistry, 12th Edition, John M. Beale, John H. Block, Walters Kluwer, 2011.
14) Teo: Antidepressants – Midterm Exam-2 Lab: Molecular Modeling Techniques 1) Foye's Principles of Medicinal Chemistry, 7th Edition, by David A. Williams and Thomas L. Lemke, Lippincott Williams & Wilkins, 2013. 2) Wilson’s and Gisvold’s, Organic Medisinal and Pharmaceutical Chemistry, 12th Edition, John M. Beale, John H. Block, Walters Kluwer, 2011.

Sources

Course Notes / Textbooks: 1) Foye Medisinal Kimya Temel İlkeleri, T.L.emke, S.W.Zito, V.F.Roche, D.A.Williams, Çev.Edit.Öztekin Algül, Kayhan Bolelli
2) Farmasötik Kimya Hacettepe Üniversitesi Yayınları ISBN: 978-975-491-171-8 3. Baskı, Aralık 2013
References: 1- Farmasötik Kimya Hacettepe Üniversitesi Yayınları ISBN: 978-975-491-171-8 3. Baskı, Aralık 2013
2- Foye's Principles of Medicinal Chemistry Publication Date: March 8, 2012 ISBN-10: 1609133455 ISBN-13: 978-1609133450 Edition: Seventh, North American Edition
3- Burger's Medicinal Chemistry, Drug Discovery and Development 7th Edition, 8 Volume Set ISBN: 978-0-470-27815-4 September 2010
4- Pharmaceutical Chemistry, David G. Watson (Author) Publication Date: February 18, 2011 ISBN-10: 0443072329 ISBN-13: 978-0443072321 Edition: 1
Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry Publication Date: March 2, 2010 ISBN-10: 0781779294 ISBN-13: 978-0781779296 Edition: Twelfth, North American Edition

Course - Program Learning Outcome Relationship

Course Learning Outcomes

1

2

3

4

5

6

Program Outcomes
1) Applies and develops the universal and social dimensional effects of basic, professional and technological knowledge in the field of pharmacy as well as pharmacy practice interdisciplinary by following legal, deontological and ethical rules. 3 3 3 3 3 3
2) Defines the terminology related to the pharmacy profession; solves problems , accesses scientific information in the field of pharmacy, after monitoring and evaluating the current literature, applies , communicates, shares by using information technologies effectively and efficiently. 2 2 2 2 2 2
3) Uses theoretical and practical knowledge about the anatomical structure of the human body, the physiological working principles of systems, biochemical, immunological events in the organism and microorganisms.
4) Uses basic and advanced analytical techniques and methods by running qualitative/quantitative analyzes and interprets the findings by using appropriate statistical methods. 2 2 2 2 2 2
5) Defines medicinal plants, herbal drugs and active substances; gains the skills for the development of natural products used for medical purposes. 1 1 1 1 1 1
6) Applies patient-centered and individualized pharmaceutical care service together with other healthcare personnel within the framework of rational drug use by using the principles of clinical pharmacy, pharmacoeconomics, pharmacotherapy and phytotherapy. 1 1 1 1 1 1
7) Knows the biological properties, structure-activity relationships, and metabolisms of drugs and gains the skill for the synthesize and development of new drug candidates. 3 3 3 3 3 3
8) He/She is competent at formulations, production, stability, quality assurance, licensing, patent studies, legal regulations of products containing natural origin and / or synthetic active substances, advanced therapy medicinal products, radiopharmaceuticals and cosmetic products.
9) Interprets the pharmacokinetic and pharmacodynamic properties of drugs, the factors that change their effect, their toxic effects, pharmacolygical activities and their risk assessment method. Reports the drug interactions and adverse drug reactions, monitors and applies the theoretical/practical knowledge for preventing them.
10) As a health professional in his/her profession he/she acts as a caregiver, decision maker, communicator, manager, lifelong learner, instructor, leader and researcher, he/she complies with the principles of evidence-based pharmacy by making teamwork for the benefit of society, national and universal values. 1 1 1 1 1 1
11) He/She works in various fields such as community pharmacy, hospitals, pharmaceutical medical devices, herbal products and cosmetics sectors, health institutions and agencies, clinical research organizations , universities and R&D centers. 2 2 2 2 2 2

Course - Learning Outcome Relationship

No Effect 1 Lowest 2 Average 3 Highest
       
Program Outcomes Level of Contribution
1) Applies and develops the universal and social dimensional effects of basic, professional and technological knowledge in the field of pharmacy as well as pharmacy practice interdisciplinary by following legal, deontological and ethical rules. 3
2) Defines the terminology related to the pharmacy profession; solves problems , accesses scientific information in the field of pharmacy, after monitoring and evaluating the current literature, applies , communicates, shares by using information technologies effectively and efficiently. 2
3) Uses theoretical and practical knowledge about the anatomical structure of the human body, the physiological working principles of systems, biochemical, immunological events in the organism and microorganisms.
4) Uses basic and advanced analytical techniques and methods by running qualitative/quantitative analyzes and interprets the findings by using appropriate statistical methods. 2
5) Defines medicinal plants, herbal drugs and active substances; gains the skills for the development of natural products used for medical purposes. 1
6) Applies patient-centered and individualized pharmaceutical care service together with other healthcare personnel within the framework of rational drug use by using the principles of clinical pharmacy, pharmacoeconomics, pharmacotherapy and phytotherapy. 1
7) Knows the biological properties, structure-activity relationships, and metabolisms of drugs and gains the skill for the synthesize and development of new drug candidates. 3
8) He/She is competent at formulations, production, stability, quality assurance, licensing, patent studies, legal regulations of products containing natural origin and / or synthetic active substances, advanced therapy medicinal products, radiopharmaceuticals and cosmetic products.
9) Interprets the pharmacokinetic and pharmacodynamic properties of drugs, the factors that change their effect, their toxic effects, pharmacolygical activities and their risk assessment method. Reports the drug interactions and adverse drug reactions, monitors and applies the theoretical/practical knowledge for preventing them.
10) As a health professional in his/her profession he/she acts as a caregiver, decision maker, communicator, manager, lifelong learner, instructor, leader and researcher, he/she complies with the principles of evidence-based pharmacy by making teamwork for the benefit of society, national and universal values. 1
11) He/She works in various fields such as community pharmacy, hospitals, pharmaceutical medical devices, herbal products and cosmetics sectors, health institutions and agencies, clinical research organizations , universities and R&D centers. 2

Assessment & Grading

Semester Requirements Number of Activities Level of Contribution
Midterms 1 % 30
Final 1 % 70
total % 100
PERCENTAGE OF SEMESTER WORK % 30
PERCENTAGE OF FINAL WORK % 70
total % 100

Workload and ECTS Credit Calculation

Activities Number of Activities Workload
Course Hours 15 30
Laboratory 15 45
Study Hours Out of Class 14 28
Midterms 2 11
Final 2 21
Total Workload 135