| Course Objectives: |
To remind about fundamental organic chemistry, some terms in organic chemisrty and reaction mechanism. Lessons are to improve the capacity of students to classify reaction type and mechanism. To ensure knowledge and skills on subjects of working in organic reaction mechanism. To teach and develop skills in organic reaction mechanism with literature examples |
| Course Content: |
Fundamental organic Chemistry. Basic terms in Organic Chemistry. Acid base definitions. Nucleophile, electrophile, carbocation, carbanion, radical. Type of arrows in Organic and mechanism Application. Discussion of Reaction mechanisms and discussion in Aldol, Claisen, Cannizaro, haloform, malonic ester, Michael reactions. Some Reaction mechanisms discussion from literature and articles. |
| Week |
Subject |
Related Preparation |
| 1) |
Introducing Course and Discussion on the Course Syllabus |
|
| 2) |
Fundamental Organic Chemistry Revision-1 |
|
| 3) |
Fundamental Organic Chemistry Revision-2 |
|
| 4) |
Fundamental Organic Chemistry Revision-3 |
|
| 5) |
Fundamental Organic Chemistry Revision-4 |
|
| 6) |
Oxidation step calculation in organic and inorganic structures. Covalent and ionic character in bonds. The concept of dipole moment. Molecule geometry. Hybridization. Aromaticity. |
|
| 7) |
Bronsted Acid-Base concept. Lewis acid-base concept. Tautomerization. Resonance (Mesomeric), Steric and Inductive effects. The effects of these on acidity and alkalinity in organic molecules. |
|
| 8) |
Assignment (presentation) |
|
| 9) |
Mechanism classes. Electrophile, Nucleophile, Leaving Group definitions and examples. Conjugation- Hyperconjugation concepts |
|
| 10) |
Arrow types and recognition in reactions. Reaction Kinetics and Thermodynamics.Types of reaction transformations (Addition, Elimination, Substitution, Rearangement). |
|
| 11) |
Carbanion and Carbocation definition and examples.Increase and decrease in stability, and energy relations. The relationship between energy and bond strength-stability. Aldol and Claisen reaction mechanisms and discussion. |
|
| 12) |
Cannizaro reaction. Benzyl Reaction mechanisms and discussion |
|
| 13) |
Fischer esterification. Haloform reaction. Benzilic acid reaction mechanisms and discussion |
|
| 14) |
Mechanism of Wittig Reaction and its applications in synthesis
Malonic ester and Michael Addition Mechanism applications.
|
|
| 15) |
Final Exam |
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ISTINYE UNIVERSITY BİLGİ PAKETİ / DERS KATALOĞU
