Molecular Oncology (DR) Preview
PhD	TR-NQF-HE: Level 8	QF-EHEA: Third Cycle	EQF-LLL: Level 8

Course Introduction and Application Information

Course Code:

MONK6011

Course Name:

Trace Elements and Minerals in Cancer

Semester:

Spring

Course Credits:

ECTS

Language of instruction:

Turkish

Course Condition:

Does the Course Require Work Experience?:

Type of course:

Departmental Elective

Course Level:

PhD

TR-NQF-HE:8. Master`s Degree

QF-EHEA:Third Cycle

EQF-LLL:8. Master`s Degree

Mode of Delivery:

E-Learning

Course Coordinator:

Dr. Öğr. Üy. DENİZHAN KARIŞ

Course Lecturer(s):

Dr. Öğr. Üy. DENİZHAN KARIŞ

Course Assistants:

Course Objective and Content

Course Objectives:

The aim of the course is to provide students with the effects of cancer at the molecular and cellular, tissue and organ levels; To teach the relationship of cancer diagnosis and treatment with trace elements and minerals.

Course Content:

Atomic theories, Basic principles of living structures, Physical properties of chemical bonds and bond energetics; Properties determining the structural and functional properties of biomolecules; DNA repair mechanisms and cancer; Chemical and physical structure of water molecule, Role of water in organism, Properties of body fluids, Intracellular electrical environment, Aqueous solutions, Buffer systems; Energy flow in living things; Laws of bioenergetics and thermodynamics; Thermodynamic-bioenergetic concepts in cancer, Cancer and cachexia; Cell injury and adaptation in cancer; Cell death, apoptosis, necrosis; Acute and chronic inflammation; cytokines; Free oxygen radicals and the damage they cause; Oxidative damage mechanisms; Antioxidants and their biological importance; Cancer and angiogenesis; cancer and immunity; Biological importance of trace elements and minerals; Biological importance of iron and copper elements and their importance in cancer process; Biological importance of chromium, cobalt and manganese elements and their importance in cancer process; Biological importance of zinc, selenium and boron and their importance in cancer process; Biological importance of mercury, lead, cadmium and aluminum elements and their importance in cancer process; Biological importance of silicon, nickel and arsenic elements and their importance in cancer process; Biological importance of minerals of calcium, phosphorus and magnesium minerals and their importance in cancer process; Biological importance of iodine, sodium, chlorine, potassium and sulfur minerals and their importance in cancer process

Learning Outcomes

The students who have succeeded in this course;
1) Discusses atomic theories, chemical bonds, biomolecular bonds, DNA repair mechanisms, chemical and physical structure of water and its importance in organisms.
2) Discusses the concept of energy in cancer.
3) Discusses the effects of cell injury, cell death, acute and chronic inflammation and cytokines in cancer.
4) Discusses oxidative damage mechanisms and biological importance of antioxidants in cancer.
5) Discusses the biological importance of trace elements and minerals.
6) Defines and discusses in detail the trace elements and minerals that are effective in cancer metabolism.
7) Studies interdisciplinary.

Course Flow Plan

Week	Subject	Related Preparation
1)	Atomic theories, Basic principles of living structures, Physical properties of chemical bonds and bond energy
2)	Properties determining the structural and functional properties of biomolecules; DNA repair mechanisms and cancer
3)	Chemical and physical structure of water molecule, Role of water in organism
4)	Properties of body fluids, Intracellular electrical environment, Aqueous solutions, Buffer systems
5)	Energy flow in living things; Laws of bioenergetics and thermodynamics; Thermodynamic-bioenergetic concepts in cancer, Cancer and cachexia
6)	Cell injury and adaptation in cancer; Cell death, apoptosis, necrosis; Acute and chronic inflammation; cytokines
8)	Cancer and angiogenesis; Cancer and immunity
9)	Biological importance of trace elements and minerals
10)	Biological importance of iron and copper elements and their importance in cancer process
11)	Biological importance of chromium, cobalt and manganese elements and their importance in cancer process
12)	Biological importance of zinc, selenium and boron and their importance in cancer process
13)	Biological importance of mercury, lead, cadmium and aluminum elements and their importance in cancer process
14)	Biological importance of silicon, nickel and arsenic elements and their importance in cancer process
15)	Biological importance of minerals of calcium, phosphorus and magnesium minerals and their importance in cancer process
16)	Biological importance of iodine, sodium, chlorine, potassium and sulfur minerals and their importance in cancer process

Sources

Course Notes / Textbooks:

• Harper's Illustrated Biochemistry 31st Edition by Robert K. Murray, 2018.
• Alberts Molecular Biology of the Cell, Robert Alberts, 2015.
• Integrated Molecular and Cellular Biophysics, Valeria Raicu ve Aurel Popescu, Çeviri editörü: Prof. Dr. Rüstem Nurten, İstanbul Medikal Yayınları, 2014.
• Biophysics Demystified, Daniel Goldfarb, 3Mc Graw Hill Publications, 2011.
• Trace Elements & Other Essential Nutrients – Dr David L. Watts, 2015.
• Essential and Toxic Trace Elements and Vitamins in Human Health, George Brewer, 2020.

References:

Course - Program Learning Outcome Relationship

Course Learning Outcomes	1	2	3	4	5	6	7
Program Outcomes
1) To be able to define, evaluate and use current and advanced knowledge of cancer and molecular cancer	2	2	2	2	2	2	2
2) To be able to research, comprehend and analyze a scientific and technological issue in the field of molecular cancer with a systematic approach.	2	2	2	2	2	2	2
3) Ability to develop, design, adapt and implement new and complex ideas about the molecular mechanisms of cancer at an expert level with original thinking and/or research	3	3	3	3	3	3	3
4) To be able to comprehend the interdisciplinary interaction with which the molecular cancer field is related, to develop a new method, design and/or application with a new idea or a known idea.	3		3	3	3	3	3
5) To gain the ability to synthesize, analyze, interpret, question and criticize information about treatment approaches developed against cancer	2	2	2	2	2	2	2
6) Tp develop new ideas and methods in the field by using high-level skills such as problem solving and decision making in their studies.	2	2	2	2	2	2	2
7) To have good communication skills in their work and being able to critically examine and develop the norms that guide these relationships, and to manage actions to change them when necessary	2	2	2	2	2	2	2
8) To have an awareness of ethical responsibility in their research and to be able to defend their findings by using advanced written, verbal and visual communication.	2	2	2	2	2	2	2
9) To contribute to the solution of social, scientific, computational and ethical problems encountered in the field of molecular cancer and to support the development of these values.	2	2	2	2	2	2	2
10) To be able to interpret research and study results and expand the limits of knowledge in the field by producing an original work.	2		2	2	2	2	2

Course - Learning Outcome Relationship

No Effect	1 Lowest	2 Average	3 Highest

	Program Outcomes	Level of Contribution
1)	To be able to define, evaluate and use current and advanced knowledge of cancer and molecular cancer	2
2)	To be able to research, comprehend and analyze a scientific and technological issue in the field of molecular cancer with a systematic approach.	2
3)	Ability to develop, design, adapt and implement new and complex ideas about the molecular mechanisms of cancer at an expert level with original thinking and/or research	3
4)	To be able to comprehend the interdisciplinary interaction with which the molecular cancer field is related, to develop a new method, design and/or application with a new idea or a known idea.	3
5)	To gain the ability to synthesize, analyze, interpret, question and criticize information about treatment approaches developed against cancer	2
6)	Tp develop new ideas and methods in the field by using high-level skills such as problem solving and decision making in their studies.	2
7)	To have good communication skills in their work and being able to critically examine and develop the norms that guide these relationships, and to manage actions to change them when necessary	2
8)	To have an awareness of ethical responsibility in their research and to be able to defend their findings by using advanced written, verbal and visual communication.	2
9)	To contribute to the solution of social, scientific, computational and ethical problems encountered in the field of molecular cancer and to support the development of these values.	2
10)	To be able to interpret research and study results and expand the limits of knowledge in the field by producing an original work.	2

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Homework Assignments	1	% 40
Presentation	1	% 60
total		% 100
PERCENTAGE OF SEMESTER WORK		% 100
PERCENTAGE OF FINAL WORK		%
total		% 100

Workload and ECTS Credit Calculation

Activities	Number of Activities	Preparation for the Activity	Spent for the Activity Itself	Completing the Activity Requirements	Workload
Presentations / Seminar	1	3	1	2	6
Homework Assignments	1	5	1	2	8
Total Workload					14