| Medical Biology and Genetics (DR) | |||||
| PhD | TR-NQF-HE: Level 8 | QF-EHEA: Third Cycle | EQF-LLL: Level 8 | ||
| Course Code: | TGY6009 | ||||
| Course Name: | Cancer Genetics | ||||
| Semester: | Fall | ||||
| Course Credits: |
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| Language of instruction: | Turkish | ||||
| Course Condition: | |||||
| Does the Course Require Work Experience?: | No | ||||
| Type of course: | Departmental Elective | ||||
| Course Level: |
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| Mode of Delivery: | Face to face | ||||
| Course Coordinator: | Dr. Öğr. Üy. ÖYKÜ GÖNÜL GEYİK | ||||
| Course Lecturer(s): | Öykü GÖNÜL GEYİK | ||||
| Course Assistants: |
| Course Objectives: | The aim of this course for each student; to learn the structure and pathology of cancer cells at molecular and genetic level. |
| Course Content: | Molecular and genetic mechanisms in cancer. |
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The students who have succeeded in this course;
1) Counts the causes of cancer development and explains its evolutionary importance. 2) Counts signaling pathways associated with growth factors and hormones involved in tumor development. 3) Explains cell cycle control mechanisms in cancer. 4) Explains the mechanisms of cancer cell death. 5) Discusses cancer metabolism by comparing it with physiological metabolism. 6) Defines the concepts of invasion, metastasis and angiogenesis and explains their importance in cancer. 7) Explain the importance of cancer microenvironment and immunology. 8) Counts DNA repair mechanisms and explains genome integrity. 9) Discusses the importance of genetic instability in cancer. 10) Explains the changes in epigenetic regulations in cancer. 11) Explains the roles of viruses, chemicals and radiation in carcinogenesis. 12) Defines oncogenesis and tumor suppression. 13) Discusses the effect and importance of telomerase regulation and immortalization in cancer. 14) Discusses the place of molecular studies in cancer research and their importance for the development of personalized medicine. |
| Week | Subject | Related Preparation |
| 1) | Cancer in the multicellular organism and evolutionary point of view | |
| 2) | Signaling pathways associated with growth factors and hormones involved in tumor development | |
| 3) | Cell cycle control and cancer cell death in cancer | |
| 4) | Respiration, response to hypoxia and cancer metabolism in cancer cells | |
| 5) | Invasion, metastasis and angiogenesis | |
| 6) | Cancer microenvironment and immunology | |
| 7) | Student presentations | |
| 8) | DNA repair and genome integration | |
| 9) | Genetic instability in cancer | |
| 10) | Cancer epigenetics | |
| 11) | Oncogenesis and tumor suppression | |
| 12) | Telomerase and immortalization | |
| 13) | Molecular profiling and personalized medicine in cancer research | |
| 14) | Final |
| Course Notes / Textbooks: | - Goodman's Medical Cell Biology, Academic Press, 2020 - Campbell Biology 10th Edition, Pearson, 2014 - William S. Klug, Michael R. Cummings, Concepts of Genetics, 11th edition, Pearson, 2014 - Cooper, G.M. The Cell: A Molecular Approach 8e, Oxford University Press, 2018 |
| References: | - Goodman's Medical Cell Biology, Academic Press, 2020 - Campbell Biology 10th Edition, Pearson, 2014 - William S. Klug, Michael R. Cummings, Concepts of Genetics, 11th edition, Pearson, 2014 - Cooper, G.M. The Cell: A Molecular Approach 8e, Oxford University Press, 2018 |
| Course Learning Outcomes | 1 |
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| Program Outcomes | ||||||||||||||
| 1) Follows the current literature in the field of Medical Biology and Genetics, collects information, analyzes and synthesizes it with appropriate evaluation methods and guides clinical practices. | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 2) Uses appropriate methods and technological structures for scientific research, establishes the appropriate hypothesis, and determines research methods. | ||||||||||||||
| 3) Interprets the results obtained as a result of scientific research, transfers and develops the evidence-based knowledge obtained into applications, presents its results at national and international scientific meetings and publishes them in peer-reviewed journals. | ||||||||||||||
| 4) Realizes the principles of lifelong learning by observing professional autonomy within the ethical, deontological and legal framework in Medical Biology and Genetics applications and scientific studies. | ||||||||||||||
| 5) Provides interdisciplinary collaboration in academic and clinical environments and has knowledge and skills in problem solving and management. | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| 6) Uses the information obtained from scientific research and literature for the benefit of society and ensures the shaping of health policies necessary to improve public health and takes part in these policies. | ||||||||||||||
| 7) Trains biologists who combine clinical experience and academic knowledge, produce, plan and implement creative solutions in the field of medical biology and have qualified knowledge and skills. | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| No Effect | 1 Lowest | 2 Average | 3 Highest |
| Program Outcomes | Level of Contribution | |
| 1) | Follows the current literature in the field of Medical Biology and Genetics, collects information, analyzes and synthesizes it with appropriate evaluation methods and guides clinical practices. | 2 |
| 2) | Uses appropriate methods and technological structures for scientific research, establishes the appropriate hypothesis, and determines research methods. | |
| 3) | Interprets the results obtained as a result of scientific research, transfers and develops the evidence-based knowledge obtained into applications, presents its results at national and international scientific meetings and publishes them in peer-reviewed journals. | |
| 4) | Realizes the principles of lifelong learning by observing professional autonomy within the ethical, deontological and legal framework in Medical Biology and Genetics applications and scientific studies. | |
| 5) | Provides interdisciplinary collaboration in academic and clinical environments and has knowledge and skills in problem solving and management. | 1 |
| 6) | Uses the information obtained from scientific research and literature for the benefit of society and ensures the shaping of health policies necessary to improve public health and takes part in these policies. | |
| 7) | Trains biologists who combine clinical experience and academic knowledge, produce, plan and implement creative solutions in the field of medical biology and have qualified knowledge and skills. | 2 |
| Semester Requirements | Number of Activities | Level of Contribution |
| Midterms | 1 | % 50 |
| Final | 1 | % 50 |
| total | % 100 | |
| PERCENTAGE OF SEMESTER WORK | % 50 | |
| PERCENTAGE OF FINAL WORK | % 50 | |
| total | % 100 | |
| Activities | Number of Activities | Preparation for the Activity | Spent for the Activity Itself | Completing the Activity Requirements | Workload | ||
| Course Hours | 4 | 4 | 4 | 32 | |||
| Study Hours Out of Class | 10 | 0 | 10 | 100 | |||
| Presentations / Seminar | 6 | 6 | 1 | 42 | |||
| Homework Assignments | 2 | 0 | 6 | 12 | |||
| Midterms | 1 | 6 | 1 | 7 | |||
| Final | 1 | 6 | 1 | 7 | |||
| Total Workload | 200 | ||||||