| Biomedical Engineering (English) | |||||
| Bachelor | TR-NQF-HE: Level 6 | QF-EHEA: First Cycle | EQF-LLL: Level 6 | ||
| Course Code: | UNI320 | ||||
| Course Name: | Health & Microbiome | ||||
| Semester: | Spring | ||||
| Course Credits: |
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| Language of instruction: | English | ||||
| Course Condition: | |||||
| Does the Course Require Work Experience?: | No | ||||
| Type of course: | University Elective | ||||
| Course Level: |
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| Mode of Delivery: | E-Learning | ||||
| Course Coordinator: | Dr. Öğr. Üy. DENİZ SERTEL ŞELALE | ||||
| Course Lecturer(s): | İbrahim Çağatay Acuner, Pınar Yurdakul Mesutoğlu, Deniz Sertel Şelale, Ayhan Mehmetoğlu | ||||
| Course Assistants: |
| Course Objectives: | The aim of this course is to convey information on; - fundamentals of human microbiota & microbiome - formation and development of microbiota - factors that affect the composition of microbiota - effects of microbiota on human health - association of microbiota with diseases - pharmaceutical modulation of microbiota |
| Course Content: | This course includes theoretical lectures regarding human microbiota and it’s effects on human health and association with diseases. |
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The students who have succeeded in this course;
1) Should be able to define microbiota, microbiome and metagenome concepts. 2) Should be able to describe human microbiota and explain how its formed. 3) Should be able to explain the factors that affect the composition of microbiota. 4) Should be able to define the effects of microbiota on human health. 5) Should be able to explain the association of microbiota with diseases. 6) Should be able to discuss the use of pharmaceutical preparations that modulate microbiota in promotion of health. |
| Week | Subject | Related Preparation |
| 1) | Introduction to microbiota, microbiome and metagenome concepts | Review of the course materials |
| 2) | Transmission and development of microbiota | Review of the course materials |
| 3) | Nutritional modulation of the gut microbiome | Review of the course materials |
| 4) | Microbiota perturbations: Dysbiosis and Disease | Review of the course materials |
| 5) | Microbiota & Obesity; Type-2 Diabetes and Cancer | Review of the course materials |
| 6) | Gut microbiome and host immunity | Review of the course materials |
| 7) | Microbiota & Gut-Brain / Gut-Lung Axis | Review of the course materials |
| 8) | Mid term exam | Review of the course materials |
| 9) | Consumption of antibiotics and microbiota | Review of the course materials |
| 10) | Fecal transplantation | Review of the course materials |
| 11) | Nutritional modulation of the gut microbiome for metabolic health and healthy longevity | Review of the course materials |
| 12) | Prebiotics, probiotics and next generation pharmaceutical modulation of the gut microbiome | Review of the course materials |
| 13) | One health approach, and microbiota | Review of the course materials |
| 14) | Multi omics approach and future trends | Review of the course materials |
| 15) | Final Exam | Review of the course materials |
| Course Notes / Textbooks: | Tungland B. Human Microbiota in Health and Disease. Academic Press;2018. ISBN 9780128146491 |
| References: | • Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci. 2012 Oct;13(10):701-12. doi: 10.1038/nrn3346. Epub 2012 Sep 12. PMID: 22968153. • Sonnenburg JL, Bäckhed F. Diet-microbiota interactions as moderators of human metabolism. Nature. 2016 Jul 7;535(7610):56-64. doi: 10.1038/nature18846. PMID: 27383980; PMCID: PMC5991619. • Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015 Apr-Jun;28(2):203-209. PMID: 25830558; PMCID: PMC4367209. • Kim S, Covington A, Pamer EG. The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens. Immunol Rev. 2017 Sep;279(1):90-105. doi: 10.1111/imr.12563. PMID: 28856737; PMCID: PMC6026851. • Sonnenburg JL, Sonnenburg ED. Vulnerability of the industrialized microbiota. Science. 2019 Oct 25;366(6464):eaaw9255. doi: 10.1126/science.aaw9255. PMID: 31649168. • Mikroorganizmalar ve insan vücudu ile olan etkileşimleri Microorganisms and their interaction with human body. Rıdvan Çetin et al. DOI: 10.5455/pmb.1-1422383762 • Tang ZZ, Chen G, Hong Q, Huang S, Smith HM, Shah RD, Scholz M, Ferguson JF. Multi-Omic Analysis of the Microbiome and Metabolome in Healthy Subjects Reveals Microbiome-Dependent Relationships Between Diet and Metabolites. Front Genet. 2019 May 17;10:454. doi: 10.3389/fgene.2019.00454. PMID: 31164901; PMCID: PMC6534069. • İntestinal mikrobiyota ve obezite ilişkisi, The relationship between intestinal microbiota and obesity. Tuba tekin et al. Derleme 2018; 27: 95-99. • Ichim TE, Patel AN, Shafer KA. Experimental support for the effects of a probiotic/digestive enzyme supplement on serum cholesterol concentrations and the intestinal microbiome. J Transl Med. 2016 Jun 22;14(1):184. doi: 10.1186/s12967-016-0945-2. PMID: 27333764; PMCID: PMC4918082. • Kuugbee ED, Shang X, Gamallat Y, Bamba D, Awadasseid A, Suliman MA, Zang S, Ma Y, Chiwala G, Xin Y, Shang D. Structural Change in Microbiota by a Probiotic Cocktail Enhances the Gut Barrier and Reduces Cancer via TLR2 Signaling in a Rat Model of Colon Cancer. Dig Dis Sci. 2016 Oct;61(10):2908-2920. doi: 10.1007/s10620-016-4238-7. Epub 2016 Jul 6. PMID: 27384052. • Salvucci E. The human-microbiome superorganism and its modulation to restore health. Int J Food Sci Nutr. 2019 Nov;70(7):781-795. doi: 10.1080/09637486.2019.1580682. Epub 2019 Mar 7. PMID: 30843443. |
| Course Learning Outcomes | 1 |
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| Program Outcomes | |||||||||||
| 1) Adequate knowledge of mathematics, science and biomedical engineering disciplines; Ability to use theoretical and applied knowledge in these fields in solving complex engineering problems. | |||||||||||
| 2) Ability to identify, formulate and solve complex biomedical engineering problems; ability to select and apply appropriate analysis and modeling methods for this purpose. | |||||||||||
| 3) Ability to design a complex system, process, device or product to meet specific requirements under realistic constraints and conditions; ability to apply modern design methods for this purpose. | |||||||||||
| 4) Ability to select and use modern techniques and tools necessary for the analysis and solution of complex problems encountered in biomedical engineering practices; Ability to use information technologies effectively. | |||||||||||
| 5) Ability to design, conduct experiments, collect data, analyze and interpret results for the investigation of complex biomedical engineering problems or discipline-specific research topics. | |||||||||||
| 6) Ability to work effectively in disciplinary and multi-disciplinary teams; individual working skills. | |||||||||||
| 7) Ability to communicate effectively orally and in writing; knowledge of at least one foreign language, ability to write effective reports and understand written reports, to prepare design and production reports, to make effective presentations, to give and receive clear and understandable instructions. | |||||||||||
| 8) Awareness of the necessity of lifelong learning; the ability to access information, follow developments in science and technology, and constantly renew oneself. | |||||||||||
| 9) Knowledge of ethical principles, professional and ethical responsibility, and standards used in engineering practices. | |||||||||||
| 10) Knowledge of business practices such as project management, risk management and change management; awareness of entrepreneurship, innovation; information about sustainable development. | |||||||||||
| 11) Information about the effects of biomedical engineering practices on health, environment and safety in universal and social dimensions and the problems of the age reflected in the field of engineering; Awareness of the legal consequences of biomedical engineering solutions. | |||||||||||
| No Effect | 1 Lowest | 2 Average | 3 Highest |
| Program Outcomes | Level of Contribution | |
| 1) | Adequate knowledge of mathematics, science and biomedical engineering disciplines; Ability to use theoretical and applied knowledge in these fields in solving complex engineering problems. | |
| 2) | Ability to identify, formulate and solve complex biomedical engineering problems; ability to select and apply appropriate analysis and modeling methods for this purpose. | |
| 3) | Ability to design a complex system, process, device or product to meet specific requirements under realistic constraints and conditions; ability to apply modern design methods for this purpose. | |
| 4) | Ability to select and use modern techniques and tools necessary for the analysis and solution of complex problems encountered in biomedical engineering practices; Ability to use information technologies effectively. | |
| 5) | Ability to design, conduct experiments, collect data, analyze and interpret results for the investigation of complex biomedical engineering problems or discipline-specific research topics. | |
| 6) | Ability to work effectively in disciplinary and multi-disciplinary teams; individual working skills. | |
| 7) | Ability to communicate effectively orally and in writing; knowledge of at least one foreign language, ability to write effective reports and understand written reports, to prepare design and production reports, to make effective presentations, to give and receive clear and understandable instructions. | |
| 8) | Awareness of the necessity of lifelong learning; the ability to access information, follow developments in science and technology, and constantly renew oneself. | |
| 9) | Knowledge of ethical principles, professional and ethical responsibility, and standards used in engineering practices. | |
| 10) | Knowledge of business practices such as project management, risk management and change management; awareness of entrepreneurship, innovation; information about sustainable development. | |
| 11) | Information about the effects of biomedical engineering practices on health, environment and safety in universal and social dimensions and the problems of the age reflected in the field of engineering; Awareness of the legal consequences of biomedical engineering solutions. |
| Semester Requirements | Number of Activities | Level of Contribution |
| Homework Assignments | 1 | % 20 |
| Midterms | 1 | % 20 |
| Final | 1 | % 60 |
| total | % 100 | |
| PERCENTAGE OF SEMESTER WORK | % 40 | |
| PERCENTAGE OF FINAL WORK | % 60 | |
| total | % 100 | |
| Activities | Number of Activities | Preparation for the Activity | Spent for the Activity Itself | Completing the Activity Requirements | Workload | ||
| Course Hours | 14 | 0 | 3 | 42 | |||
| Homework Assignments | 1 | 20 | 1 | 21 | |||
| Midterms | 1 | 30 | 1 | 31 | |||
| Final | 1 | 30 | 1 | 31 | |||
| Total Workload | 125 | ||||||