Molecular Biology and Genetics (English) Preview
Bachelor	TR-NQF-HE: Level 6	QF-EHEA: First Cycle	EQF-LLL: Level 6

Course Introduction and Application Information

Course Code:

MBG301

Course Name:

Human Genetics

Semester:

Fall

Course Credits:

ECTS

Language of instruction:

English

Course Condition:

Does the Course Require Work Experience?:

Type of course:

Compulsory Courses

Course Level:

Bachelor

TR-NQF-HE:6. Master`s Degree

QF-EHEA:First Cycle

EQF-LLL:6. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator:

Araş. Gör. KAAN ADACAN

Course Lecturer(s):

Prof. Dr. VEYSEL SABRİ HANÇER

Course Assistants:

Course Objective and Content

Course Objectives:

Identification of human genetics and terms, teaching molecular mechanisms of monogenic, polygenic, chromosomal and mitochondrial inheritance diseases in the guidance of OMIM database and current articles and to give information about immunogenetics, cancer genetics and pharmacogenetics.

Course Content:

DNA and RNA structure, chromosomes, human genome organization and gene expression, mutations in human genome and DNA repair, genetic mapping, genome project, determination of human disease genes, molecular pathology, genetic analysis in individuals and populations, cancer genetics, complex diseases, genetic manipulation, gene therapy and other genetically based therapeutic approaches, pharmacogenetics

Learning Outcomes

The students who have succeeded in this course;
1) Can define human genetics and to distinguish types of genetic changes,
2) Can distinguish the molecular mechanism of Mendel based hereditary genetic diseases and non-Mendel based hereditary genetic diseases,
3) Can comprehend the inheritance of hereditary genetic diseases using genetic information,
4) Are able to diagram the molecular mechanism of inherited genetic diseases with the help of advanced molecular biology techniques,
5) Understand molecular genetic and mechanisms of immunogenetics.

Course Flow Plan

Week	Subject	Related Preparation
1)	Introduction to human genetics
2)	Overview of the genome structure
3)	Human genome
4)	Chromosomes, gene structure
5)	Chromosomal basis of the human disorders
6)	Paterns of single-gene inheritance
7)	Cytogenetics
8)	Midterm Exam
9)	Complex inheritance of common multifactorial disorders
10)	Mutation detection methods
11)	Non-Mendelian inheritance prenatal diagnosis
12)	Cancer genetics
13)	Immunogenetics
14)	Pharmacogenetics

Sources

Course Notes / Textbooks:	Thompson & Thompson Genetics in Medicine, R Nussbaum, RR. McInnes, HF Willard, 7 edition, Saunders, 2007
References:	Yoktur

Course - Program Learning Outcome Relationship

Course Learning Outcomes	1	2	3	4	5
Program Outcomes
1) Has a theoretical and practical background in biology, chemistry, physics and mathematics, which constitute the basic knowledge in the field of molecular biology and genetics.
2) Can explain biological phenomena and events at molecular level and relate them to other basic sciences and engineering applications.
3) Has the basic laboratory knowledge and skills required by the field.
4) Works in accordance with scientific principles and ethical rules.
5) Uses procedural and mathematical software programs required for the analysis and basic evaluation of biological data at least at the European Computer License Basic Level.
6) Has the knowledge, culture and skills to follow the literature and current methods related to his field.
7) Will be able to identify the main problem in line with the needs in health, agriculture, animal husbandry, environment, industry and similar issues and offer the necessary solutions by using up-to-date technology.
8) Has the knowledge and ability to evaluate biological phenomena and events at the level of systems from an evolutionary point of view.
9) Has the ability to be involved in individual and group work, to prepare and carry out projects on specific topics, and to make written and oral presentations.
10) Uses at least one foreign language in reading, writing and speaking at B1 General Level in terms of European Language Portfolio criteria.
11) Has the ability to identify social and global problems using his / her field knowledge and to be a part of the solution in interdisciplinary cooperation.
12) Respects social, cultural and individual differences, universal values and human rights in his / her scientific and professional activities.

Course - Learning Outcome Relationship

No Effect	1 Lowest	2 Average	3 Highest

	Program Outcomes	Level of Contribution
1)	Has a theoretical and practical background in biology, chemistry, physics and mathematics, which constitute the basic knowledge in the field of molecular biology and genetics.
2)	Can explain biological phenomena and events at molecular level and relate them to other basic sciences and engineering applications.	2
3)	Has the basic laboratory knowledge and skills required by the field.
4)	Works in accordance with scientific principles and ethical rules.
5)	Uses procedural and mathematical software programs required for the analysis and basic evaluation of biological data at least at the European Computer License Basic Level.
6)	Has the knowledge, culture and skills to follow the literature and current methods related to his field.
7)	Will be able to identify the main problem in line with the needs in health, agriculture, animal husbandry, environment, industry and similar issues and offer the necessary solutions by using up-to-date technology.
8)	Has the knowledge and ability to evaluate biological phenomena and events at the level of systems from an evolutionary point of view.
9)	Has the ability to be involved in individual and group work, to prepare and carry out projects on specific topics, and to make written and oral presentations.
10)	Uses at least one foreign language in reading, writing and speaking at B1 General Level in terms of European Language Portfolio criteria.
11)	Has the ability to identify social and global problems using his / her field knowledge and to be a part of the solution in interdisciplinary cooperation.
12)	Respects social, cultural and individual differences, universal values and human rights in his / her scientific and professional activities.

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Midterms	1	% 40
Final	1	% 60
total		% 100
PERCENTAGE OF SEMESTER WORK		% 40
PERCENTAGE OF FINAL WORK		% 60
total		% 100

Workload and ECTS Credit Calculation

Activities	Number of Activities	Preparation for the Activity	Spent for the Activity Itself	Completing the Activity Requirements	Workload
Course Hours	13	0	3		39
Study Hours Out of Class	13	0	3		39
Midterms	1	0	10		10
Final	1	0	20		20
Total Workload					108